北医三院生殖医学中心讲义 王志燮教授.pptVIP

PCOS——IGF IGF-I plays a key role in oocyte maturation in PCOS patients Alterations in IGFBP-3 concentration during stimulation may be a critical mechanism in modulating IGF-I activity PCOS patients : Mean serum IGF-I and IGFBP-3 levels increased during stimulation Serum IGF-I levels decreased higher mean number of immature oocytes retrieved (4.8±1.1 vs. 2.4±0.4; P.02) Serum IGFBP-3 levels increase greater pregnant (P.03) ongoing pregnancy (P.02) Fertil Steril 2007;88:139–44 Cytokine Family a large family of soluble polypeptide regulators interleukins (IL1~35) Leukemia Inhibitor