双重阻断RASS对2型糖尿病肾病血管生长调控因子表达的影响.docVIP

双重阻断RASS对2型糖尿病肾病血管生长调控因子表达的影响 秦会娟1△,温玉洁1※,刘陶文2，阳晶晶1 （广西壮族自治区南溪山医院暨桂林医学院附属南溪山医院 1内分泌科,2肿瘤科,广西 桂林 541002） 摘要：目的 探讨双重阻断肾素-血管紧张素-醛固酮系统（renin-angiontensin Ⅱ-aldosterone system，RASS）对2型糖尿病肾病血管生长调控因子表达的影响。方法 将糖尿病肾病（DN）患者60例，随机分为3组，实验组A.贝那普利组10mg/ 日 B.厄贝沙坦组150mg/日C.贝那普利组10mg/日、厄贝沙坦150mg/ d联合应用组各20例。用药前、后（两个月）各留取空腹血5ml用来检测血清VEGF和ENS。并对用药前后的尿微量白蛋白排泄率（UAER）作一比较。D组：空白对照组为同一时间段在我院体检中心体检的人员20例，不加任何干预。结果 实验组VEGF、ENS水平均较对照组升高P0.01；药物干预后，3组UAER、VEGF、ENS水平均有下降，联合用药组下降更明显P0.05。结论 研究证实VEGF和ENS平衡的紊乱在DN的发生发展过程中起重要作用，双重阻断RAS可明显减少尿蛋白，延缓肾脏病变。 关键词：双重阻断；RASS；糖尿病肾病；VEGF；ENS. 中图分类号：R587.2 文献标志号：A 文章编号： Dauble blockade of RASS on type 2 diabetic nephropathy vascular growth regulatory molecules expression influence QIN Hui-juan1, WEN Yu-jie1,LIU Tao-wen2. (1.Department of Endocrinology, Guilin Medical University Nanxishan Hospital of Guangxi Zhuang Autonom ous Region, Guilin 541002, China;2.Department of Oncology, Guilin Medical University Nanxishan Hospital, Guangxi Zhuang Autonomous Region, Guilin 541002, China) Abstract: Objective To investigate the dual blockade of the renin - angiotensin - aldosterone system ( renin-angiontensin II - aldosterone system, RASS ) on type 2 diabetic nephropathy vascular growth regulatory molecules expression influence. Methods diabetic nephropathy ( DN ) in 60 patients, were randomly divided into 3 groups, the experimental group A benazepril group 10mg / d B. Irbesartan group 150mg /d C benazepril group 10mg / D, 150mg / D irbesartan combined with 20 cases in each group. Before treatment, later (two months ) all take the fasting blood 5ml used to detect serum VEGF and ENS. The analyses of urine albumin excretion rate ( UAER ) to make a comparison. Group D: blank control group for the same time period in our hospital physical examination center of the medical staff in 20 cases, without any intervention. Results the VEGF, ENS levels than those in the control group P 0.01; drug intervention, 3 groups of UAER, VEGF, ENS levels drop, the c