交联透明质酸凝胶薄膜的制备和性能表征-南京师范大学学报.PDF

7 1 () Vo.l 7 No. 1 2007 3 JOURNAL OF NAN JING NORMAL UN IVERSITY ( ENG INEERING AND TECHNOLOGY EDIT ION ) M r, 2007 交联透明质酸凝胶薄膜的制备和性能表征 1, 2 1, 2 1, 2 聂素云 , 卢文庆 , 邹孔标 ( 1. , 210097; 2. , 210097) [] (ADH )(HA ), HAADH . HA- ADH . DSC, . , , SEM . HA HAADH [ ] 1469 dL /g 2021dL /g. HAADH HA, . [] , , , [] O629. 12 [] B [ ] 2007) Preparation and Characterization of C rosslink ed H yaluronan H ydrogel F ilm s N ei S uy un1, 2, LuW enq ing1, 2, Zou Kongb iao1, 2 ( 1. J i ngsu Engin eering Rese rch C enter of B io- M edic lFunction lM teri ls, 2. School of Chem istry nd Env ironm ent l Science, N njing Norm lUn iversity, N njing 210097, Ch in ) A bstract: H y luron n ( HA ) w s chem ic lly mod ified w ith d ipic d ihydr zide ( ADH ), nd physicochem ic l proper ties of the d ifferent crosslinked dens ity HAADH w ere stud ied. HAADH film s w ere prep red w ith solvent ev por tion m ethod. A fter crosslink ing, differenti l sc nn ing c lormi etric n lysis indic ted th t m icrostructure of the prod uct w s obviously ltered. The dried film h d strong bility ofw ter upt ke, nd h ighly porous newt ork structurew s detected by sc nn ing electron m icrogr ph, fter the film swelled in buffer. Intrinsic viscosity [ ] w s me sured w ith viscosity m ethod, nd [ ] ofHA nd HAADH re 14. 69 dL /g nd 20. 2 1dL /g , respectively. Therew s not ble decre se in solub ility ofHAA DH film, comp red w ithHA film, which cou ld prolong the reserv tion tmi e of the poly m er in vivo. K ey w ord s: crosslinked hy luron n, film, intrinsic viscosity, w ter upt ke b ility 0 引言 (Hy luron