内皮祖细胞在炎症损伤修复中的作用和机制.PDFVIP

20 2 Vol. 20, No. 2 2008 4 Chinese Bulletin of Life Sciences Apr., 2008 1004-0374(2008)02-0225-06 ( ICU 200025) (endothelial progenitor cells EPCs) EPCs EPCs EPCs EPC s EPCs 9 EPCs EPCs EPCs EPCs EPCs Q2; R364.5 A Effect and mechanism of endothelial progenitor cells in repair of inflammatory injury HUANG He, TANG Yao-qing* (Department of Surgery Intensive Care Unit, Shanghai Jiaotong University Affiliated Ruijin Hospital, Shanghai 200025, China) Abstract: Endothelial progenitor cells (EPCs), derived mainly from bone marrow, are the precursor cells that can differentiate to mature endothelial cells (ECs) postnatally. The level of circulating EPCs may change when impairment of vascular ECs occurs under many pathologic conditions. Extensive studies have demonstrated that EPCs participate in the repair of inflammatory injury. In addition, the changes of circulating EPCs level have been shown to be associated with the degree of inflammatory injury of blood vessel endothelium and prognosis of diseases. EPCs participate in the endothelium repair by performing mobilization, migration, homing and differentiation. The major mechanisms underlying the differentiation of EPCs to ECs are that stroma cell-derived factor and vascular endothelial growth factor secreted from injured tissues in inflammation can bind to the receptors on EPCs to modulate reparative process through activation of eNOS and matrix metalloproteinase 9 and other pathways. Furthermore, EPCs can promote the proliferation and differentiation of adjacent ECs thro