血清尿酸超敏C反应蛋白与冠状动脉慢血流现象-第三军医大学学报.DOC

超敏C反应蛋白与冠状动脉慢血流现象的关系? 赵睿? 基金项目：重庆市自然科学基金(CSTC,2008BB5077)。? 通讯作者，E-mail: HYPERLINK mailto:qshe98@ ? 基金项目：重庆市自然科学基金(CSTC,2008BB5077)。 ? 通讯作者，E-mail: HYPERLINK mailto:qshe98@ qshe98@。 重庆市第九人民医院 ICU 400700 重庆医科大学附属第二医院 心内科 400010) 摘要：目的 探讨血清超敏C反应蛋白（high-sensitivity C-reactive protein, hs-CRP）与冠状动脉慢血流现象（slow coronary flow， SCF)的关系。方法 入选通过TIMI帧计数（thrombolysis in myocardial infarction frame count, TFC）诊断为SCF的病人28例（64.3±9.0岁）及健康对照组28（61.8±12.7岁）例，测定其血清hs-CRP水平。线性相关及多元回归分析hs-CRP与SCF的关系。结果 SCF组与对照组在年龄、性别、吸烟、体重指数等基本临床资料上比较具有一致性。SCF组hs-CRP(4.01±1.32 mg/L VS. 2.96±1.03 mg/L, P=0.002)水平与对照组比较有统计学差异，hs-CRP (r = 0.68, P0.001）与Mean TFC 明显相关。多元回归分析显示hs-CRP（χ2=4.714，β=0.730, P=0.030）是SCF的独立危险因素。 结论 升高的hs-CRP水平可能参与SCF的形成过程。 关键词：超敏C反应蛋白；冠状动脉慢血流；炎症反应 中图分类号：R543.3 文献标识码：A High-sensitivity C-reactive protein in patients with slow coronary flow ZHAO Rui1，SHE Qiang2? (1. Chongqing Ninth People Hospital, Chongqing 400700, China; 2. The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Abstract: Objective To explore the correlation between serum levels of high-sensitivity C-reactive protein (hs-CRP) and slow coronary flow (SCF). Methods 28 patients（64.3±9.0 years）with documented slow coronary flow, as well as 28 patients（61.8±12.7 years）with normal coronary flow, defined by TIMI frame count (TFC), were recruited into our study. Serum levels of hs-CRP were measured in all subjects. Linear correlation and multiple regression analysis were performed for statistical analysis to establish the correlation between hs-CRP and SCF. Results There was no statistical significance between SCF group and control group with regard to age，sex, smoking，body mass index and other baseline data. The levels of hs-CRP (4.01±1.32 mg/L VS. 2.96±1.03 mg/L, P=0.002) was significantly higher in slow coronary flow patients compared to control group. The mean TFC was correlated with hs-CRP (r = 0.68, p0.001). Multiple regression analysi