寻常型银屑病患者白细胞介素-23水平的变化及其临床意义.docVIP

［作者简介］刘军麟，男，医学博士，副教授、副主任医师，研究方向：银屑病的发病机制，发表论文20余篇。电话：089866808207，手机电子邮箱：liujunlin0759@163.com 寻常型银屑病患者白细胞介素-23水平的变化及其临床意义 刘军麟1，邹循辉2，殷梅3 （570311 海口，海南省农垦总医院皮肤科1；516008 惠州，广东省惠州市皮肤病医院2；570311 海口，海南省农垦总医院体健中心3） [摘要] 目的 探讨寻常型银屑病患者血清白细胞介素（Interleukin, IL）-23水平与银屑病面积和严重程度指数（Psoriasis Area and Severity Index, PASI）及治疗转归的关系。方法 应用酶联免疫吸附法 (Enzyme Linked Immunosorbent Assay, ELISA) 检测39例寻常型银屑病患者血清IL-23的水平，评估其与PASI之间的关系并动态观察治疗前后的变化。结果 寻常型银屑病患者治疗前血清中IL-23的水平较正常对照组高（t=6.469，P0.001），且与PASI呈正相关(r=0.52，P0.05)。治疗4w及8w后血清中IL-23、PASI均较治疗前明显下降(分别为q=3.832~5.767，P均0.05；q=12.73~48.26，P均0.05)。结论 IL-23在寻常型银屑病的发病中可能起重要作用，其血清水平可作为疾病严重程度以及疗效评估的指标之一。 [关键词] 寻常型银屑病；白细胞介素-23 Clinical Significance of Serum Interleukin-23 in LIU Junlin1, ZOU Xunhui2, YIN Mei3 (1Department of Dermatology, Hainan Nongken General Hospital, Haikou, Hainan Province, 570311, China; 2Huizhou Municipal Hospital of Dermatology, Huizhou, Guangdong Province, 516008, China; 3Medical Examination Center, Hainan Nongken General Hospital, Haikou, Hainan Province, 570311, China) [Abstract] Objective To investigate the relationship of serum levels of interleukin (IL)-23 in psoriasis vulgaris patients with PASI and the change of it before, after treatments. Methods Serum levels of IL-23 were measured by ELISA in 34 patients with psoriasis vulgaris and in 51 healthy controls, then the difference between this two groups were studied. We also explored the correlation between IL-23 in patients and PASI, as well as the change of IL-23 in patients before and after treatments. Results The IL-23 levels in patients before treatment were higher than those in controls（t=6.469，P0.001） and were correlated with PASI (r=0.52, P0.05). Both IL-23 and PASI decreased 4 weeks and 8 weeks after treatment (q=3.832~5.767, P0.05； q=12.73~48.26，P 0.05, respectively). Conclusions IL-23 plays an important role in the pathogenesis of psoriasis vulgaris and might be used as an index in evaluating psoriasis and treatment outcome. [Key wo