基于b样条曲线描述的形状扩散光学层析成像算法研究-生物医学工程专业论文.docxVIP

ABSTRACT Diffuse optical tomography (DOT) has received considerable attention which can provide vast quantities of the functional information of tissues. However, the reconstruction problem of the traditional voxel-based DOT is highly ill-posed, which seriously affects the algorithms accuracy and sensitivity. In this paper, the shape-based image reconstruction algorithm of DOT is proposed based on B-spline curve description, and the boundary element method is proposed for solving the forward problem. Researches carried out in this thesis are as follows: Firstly, the boundary element method is proposed for numerically computing the forward problem, which derives the boundary integral equation. In addition, the ellipsoid parametric description and B-spline curve description are developed to describe the shape of the organization. Compared with the numerical results calculated by the finite element method and Monte Carlo simulation, the boundary element method is proved to implement the calculation of light flow effectively. Secondly, the framework of the shape-based DOT image reconstruction algorithm is constructed. Levenberg-Marquardt is employed for solving the least squares method. And optical parameters and shape parameters are reconstructed synchronously. Compared with the results calculated by the voxel-based image reconstruction algorithm, the shape-based image reconstruction algorithm is proved the reliability and superiority in tissue optical imaging. Thirdly, the three groups of the numerical simulation with different shape description methods are designed. By the use of ellipsoid parametric description, B-spline curve description and the traditional Fourier series expansion description, the contrast results validate the convergence ability and the robustness to the noise.What’s more, the influence of various parameters on the reconstruction results are discussed. Finally, the phantom experiments are implemented by the steady-state multi-channel single pho