青海地区血清中MIC-1与CEA、CA724、CA50联合检测在胃癌诊断中的意义.pdfVIP

青海大学医学院2010 级攻读临床医学硕士研究生毕业论文 3. The area under the ROC curve of MIC-1 was closer to 1, the area under the curve is better than that of CEA, CA724, CA50 and the sensitivity of MIC-1 may be superior to CEA, CA724, CA50. In serum of gastric cancer patients MIC-1、CEA、 CA724 and CA50 Ⅰ-Ⅳ area under the ROC curve respectively were ：MIC-1：1， 1，1，1；CEA ：0.4236 ， 0.8943，0.9224 ，0.9575 ；CA724 ：0.5665 ，0.9098， 0.9126，0.9594 ；CA50 ：0.6552，0.8517，0.8143，0.8973. Area under the ROC curve of MIC-1, CEA, CA72-4 and CA50 increased with clinical stage increasing. 4. The sensitivity of MIC- 1, CEA, CA724 and CA50 in gastric cancer patients were 88.7% ，63.1% ，71.6% ，36.2% respectively. The sensitivity of combined detection were 90.7%、92.9%、90.8% respectively. Sensitivity of four kinds of tumor markers for combination detection was 96.4%. Consequently, four kinds of tumor markers joint detection can improve gastric cancer diagnosis. Conclusions: MIC - 1 is a new effective gastric cancer tumor maker. It was significantly increased in serum, and decreased after treatment. The expression level of MIC-1 in serum increased with clinical stage increasing. MIC-1 can reflect the dynamic changes in patients with tumor. The combination detection of tumor markers in gastric cancer have important clinical value in improving diagnosis, reducing the ratio of failure diagnosis，monitoring curative effect. It can provide reference for clinical practical work. Key words: Gastric cancer;CEA;CA724;CA50;MIC-1; ELISA ； 第4 页 共37 页 青海大学医学院2010 级攻读临床医学硕士研究生毕业论文 前 言 胃癌是恶性程度高、发展迅速的临床常见肿瘤，其发病率居所有恶性肿瘤的 [1] 第四位，死亡率为第二位 。我国是胃癌高发区，而青海地区是我国胃癌的高发 区。在我国胃癌呈现发病率高，死亡率高，早期诊断率低，手术根治率低，五年 生存率低及预后差的特点。因此，对于胃癌的早期诊断、早期治疗及改善预后是 我们亟待解决的问题。