基因单核苷酸多态性与iga肾病及系统性红斑狼疮的相关性分析-动物学专业论文.docxVIP

agents, and availability of renal dialysis and transplantation. Despite this, however, the potential for significant morbidity and mortality remains in the group of patients with partially responsive or treatment resistant disease. In order to elevate the effectiveness of therapia and manipulation in SLE, it is necessity to elucidate the etiology and pathogenesy of SLE. Some investigation had shown that SLE likely involving numerous genes which leads to inconsistent findings in genetic studies. In our study, in order to investigate the association between Polymorphism and IgA nephropathy as well as Systemic lupus erythematosus, a large-scale evaluation of 22 Single Nucleotide Polymorphisms of 14 candidate genes was undertaken using the Sequenom? MassARRAY? system in Chinese southern Han’s males. investigation of SNPs have been the contents and objective of the human genome project. Our study will contribute effects to elevate the effectiveness of therapia and manipulation in IgAN and SLE. At the same time, it may provid an important clue for the diagnosticate of IgAN and SLE. In this experiment, CTLA4rs231726 and CR2rs1048971 revealed a significant association with IgA nephropathy, and STAT4rs7574865 and TYK2rrevealed a significant association with SLE. In addition, there were two significant differences in allele frequency between SLE and the matched controls for all of the 22 SNPs(rs7574865 and rs294183, separately). These findings support the multigenic nature of the etiology of IgA nephropathy and propose a potential gene–gene interactive model for future studies. Keyword: Sequenom MassARRAYTM iPLEXTM Assay; Single Nucleotide Polymorphism; Genotyping; IgA nephropathy; Systemic lupus erythematosus. 目 录 中文摘要 ……………………………………………………………………….Ⅰ Abstract………………………………………………………………………….Ⅲ 第一章 前言 ………………………………………………………………….1 1.1 IgA 肾病介绍……………………………………………………………...1 1.2 系统性红斑狼疮介绍…………………………………………………….2 1.3 单核苷酸多态性介绍…………………………………………………….3 1.4 单核苷酸多态性检测方法…