约氏乳酸杆菌BS15对小鼠脂肪沉积和非酒精性脂肪肝的影响.pdf

and Effect BSl5Oilfataccumulation ofLactobacillusjohnsonii in dietinducedmice NAFLD high-fat obesity ABSTRACT effectofLactobacillusBS15on and To the johnsonii obesity investigate two liver 20maleICRmiceweredividedinto nonalcoholic fatty disease(NAFLD)，1 andadministeredwitheither BS1 groups PBS(PH7．0)烈Dgroup)or5(daily amountsofeither2×107 2×108 cfu，L-BSl5 cfu，H—BSl5group)by group；or a17-week micewerefedwithnormal gavagethroughout experimentalperiod．The chow weeksbeforethe 35 PBS diet(NCD)five experimentalperiod．Afterdays，The dietthe andBS15 wasalsodividedintoNDandHFD of HFD group groups．The was into fatfortherestoftheweeks。The time groupschangedhigh samplingpoints was 19 ofthe wereasfollows： 35，63，91，1days experiment．Results 1．The ofthemiceinHFD was thanND bodyweight groupsignificanthigher at ofthe dosesofBS15 grouptheend experiment．Both supplementation increaseof duetothe diet suppressedthebodyweight high-fatconsumption． frommiceofHFD exh