从骨关节炎指南变迁看NSAIDs在OA治疗中意义.pptVIP

1 促合成作用 软骨基质生物合成的底物，促进软骨细胞的生物合成和细胞外沉淀[1,2]； 提高人软骨细胞合成蛋白聚糖的基因表达[3,4]； 2 抗分解作用 抑制软骨基质分解酶活性(基质降解酶、胶原酶、磷脂酶A2、软骨蛋白聚糖酶)[5-6]； 增加软骨细胞对纤维连接蛋白的亲和力[7]； 3 抗炎作用 降低关节滑液内IL-1β水平[8] 抑制前列腺素类物质合成[9-10] 抑制氧自由基生成[9-10] 抑制溶酶体酶活性[9-10] 抑制NO合成[11] Source: [1] Pharmacol Res Commun, 1978; 10: 557–569; [2] Osteoarthritis Cartilage,1998; 6: 427–434 [3] Osteoarthritis Cartilage, 2000; 8:207–212 [4] Osteoarthritis Cartilage, 1997; 5: 72 [5] Arthritis Rheum, 1999; 42: S253 [6] Biochem J, 1998; 335: 59-66 [7] Osteoarthritis Cartilage; 1998; 6: 393–399 [8] XIV European League against Rheumatism Congress, Glasgow, June 1999 [9] Arzneimittelforschung, 1991; 41: 157–161 [10] Arzneimittelforschung, 1991; 41: 542–545 [11] Osteoarthritis Cartilage; 1998; 6: 393–399 硫酸氨基葡萄糖药理作用 BRUYERE O,PAVELKA K,ROVATIL C,et al,Glucosam ine sulfate reducesosteoarthritis progression in postmenopausal women with knee osteoarthritis：evidence fron two 3-year studies[J].Menopause,2004,11(2)：138-143. THIE N M, PRASAD N G, MAJOR P W, Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomand joint osteoarthritis:a randomized double blind controlled 3 month clinical[J].J Rheumatol, 2001,28(6):1347-1355. OIUGX,GAO SN,GIACOVELLG,et al. Efficacy and safety of glucosam sulfate versus ibuprofen in patients with knee osteoarthritis[J].Arzneim ittelforshung,1998,48(5):469-474. LOPES V A.Double-blind clinical evaluation of the relation efficacy of ibuprofen and glucosan ine sulphate in the management of osteoarthrosis of the knee in out-patients[J].Curr Med Res Opin,1982,8(3):145-149. NOACKW, FISCHER M ,FORSTER K K,et al. Glucosamine sulfate in osteoarthritis of the knee[J].Osteoarthritis Cartilage,1994,2(1):51-59. REGNSTER J Y, DEROISYR, ROVATIL C ,et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-contrlled clinic