磁共振频谱MRS一.PDF

磁共振頻譜 MRS (一) History of NMR 1924 Pauli Proposed the existance of nuclear spin 1924 SternGerlach Directly detect nuclear magnetic moment 1946 Turning point of NMR spectroscopy Bloch, Hanson, Packard (Stanford) H2O signal (7.8 MHz) Purcell, Torry, Pound (Harvard) Paraffin wax (30.0 MHz) 1949 Torry theory for pulsed NMR 1950’s The first commercial NMR spectrometer 1951 Hahn first successful pulsed NMR measurement 1952 Bloch, Purcell won the Nobel prize 1966 Ernst, Anderson adopted Fourier transformation technique to pulsed NMR 1966 the Golden age of pulsed FT NMR pulse sequence, spin echo, multiple quantum NMR 2D,3D,4D NMR 1972 Lauterbur (Stonybrook) NMR image 1992 R. R. Ernst Nobel prize in chemistry Tasks of NMR High Resolution Spectra MRI • Conformation • morphological/anatomical • diffusion • molecular dynamics • perfusion • biomacromolecule 3D structure • blood flow • cerebral function • ligand-binding interaction MRS • protein folding-unfolding • metabolite MRI 的成像過程 • 磁場 磁化現象 • 射頻脈衝 磁化量激發 • 梯度磁場 切面選擇 • 梯度磁場 空間編碼(相位編碼、頻率編 碼) • 信號取樣(接收線圈取樣頻率) • 影像計算 如果關閉梯度磁場 • 磁場 磁化現象 • 射頻脈衝 磁化量激發 • 梯度磁場 切面選擇 • 梯度磁場 空間編碼(相位編碼、頻率編 碼) • 信號取樣(接收線圈取樣頻率) • 影像計算 B 0 B M 0 0 RF FT 除了水的訊號是否還有別的