基因突变检测在个体化用药中的研究进展.PDF

·1002 · 现代药物与临床 Drugs Clinic 第 33 卷 第 4 期 2018 年 4 月 基因突变检测在个体化用药中的研究进展 李 静，郑伶利，陈 静，袁明勇* 成都医学院第一附属医院，四川 成都 610500 摘 要：随着药物基因组学的飞速发展，遗传因素对药物代谢个体差异的影响越来越受到重视。WHO 提出 21 世纪，人类 的健康问题将逐渐步入预防医学、预测医学和个体化医疗的“3P ”时代，而这一理念已成为医学现实。临床药学是未来医 院药学服务调整的重要方向，个体化给药是临床药学服务的最终目标。综述了近年来开展最多的与临床药物基因检测有关的 项目，并对当前的个体化给药信息和医院药学部门开展基因检测工作的必要性和前瞻性做了深入的探讨。 关键词：药物基因组学；个体化给药；基因检测 中图分类号：R981 文献标志码：A 文章编号：1674 - 5515(2018)04 - 1002 - 07 DOI: 10.7501/j.issn.1674-5515.2018.04.060 Research progress on application of detection of gene mutation in individualized medication LI Jing, ZHENG Lin-li, CHEN Jing, YUAN Ming-yong The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China Abstract: The influence of genetic factorson drug metabolism is becoming more and more important with the rapid development of pharmacogenomics. WHO proposed that human health problems would gradually enter the 3P (preventive, predictable, and personal) medical age in twenty-first century, and this idea has become a medical reality. Clinical pharmacy is the important direction of the future hospital pharmacy service, and individualized drug delivery model will become the ultimate goal of clinical pharmacy service. Recently the projects related to gene detection about drug are reviewed in this article, and personalized medicine information at present and the necessity and prospect of carrying out genetic testing in the Department of Pharmacy are further discussed. Key words: pharmacogenomics; individualized administration; gene detection 药物进入人体后，通常要经过吸收、转运、代 药后是否产生耐受，能否继续用药，都必须基因检 谢、受体结合（或与靶酶结合）等过程才能发挥药 测来鉴定，若盲目使用靶向药物，不经过基因检测 理作用，如果基因突变则可能造成药物代谢过程中 确定用药方案，不仅起不到治疗效果，还会加重患 [2-4] 相关代谢酶、受体、转运体等功能的差异，这些差