nk细胞了淋巴瘤讲义.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * Intestine Testis Muscle 结外NK/T细胞淋巴瘤的免疫表型 CD2 + 表面 CD3 -; 胞浆 CD3 + (polyclonal CD3?; PS1) CD56 +, CD57和CD16常- CD4, CD5, CD7, CD8: 常- CD43, CD45RO: 常+ 细胞毒颗粒 + Ki67 : 高 CD25和 CD30偶尔+ TCR-; CD3 CD5 CD56 Granzyme B Extranodal NK/T cell lymphoma: Genotype TCR genes: germline in most cases studied EBV Present in clonal episomal form Nasal: 95% positive, irrespective of ethnic origin Extra-nasal: 90% positive in Asians, but lower % in Caucasians Extranodal NK/T cell lymphoma: Main problems in diagnosis Biopsies may show extensive coagulative