帕金森病的神经付保护治疗王训.pptVIP

* * * * * * * * * * * * * * * * * * * 14d龄胎鼠中脑神经细胞 绿色：抗β微管蛋白III； 突触素：体现神经元的结构和功能状态； DAPI即4,6-二脒基-2-苯基吲哚(4,6-diamidino-2-phenylindole)，是一种能够与DNA强力结合的荧光染料，它可以用于活细胞染色。 * * * TABLE 1. Failed clinical trials of disease-modifying therapies for PD from 2013 to 2015 Kalia LV, Kalia SK, Lang AE. Disease-modifying strategies for Parkinsons disease. Mov Disord. 2015. 30(11): 1442-50. Study Drug Mechanism of Action Trial Design Subjects Follow-up Period Primary Outcome Measure(s) Results Olanow et al., 20156 AAV2-Neuturin (injection into bilateral SNpc and putamen) Neuro trophic factor Multi-center, ran