联合用药抗前列腺癌作用及机理研究化学工程专业论文.docxVIP

优秀毕业论文 精品参考文献资料 广东工业大学硕士学位论文的用药浓度。低浓度多烯紫杉醇和降低胆固醇药物联合应用，可增强化疗的效果，减 广东工业大学硕士学位论文 的用药浓度。低浓度多烯紫杉醇和降低胆固醇药物联合应用，可增强化疗的效果，减 少化疗的毒副作用及耐药性，低浓度多烯紫杉醇和其他药物联合用药，或可称为一种 全新的更为有效的治疗前列腺癌的方向。药物联合使用或可成为治疗前列腺癌的有效 方法。 关键词：联合用药；前列腺癌；多烯紫杉醇；阿托伐他汀 Ⅱ 万方数据 AbstraetAb Abstraet Ab stract Prostate cancer(PCa)is the second most common cancer in men．PCa accounts Nghest for the newly diagnosed cancers in recent years，especially in elder men．The death rate is higher than other cancers．Consequently，it is urgent to gain a better understanding on the mechanisms driving PCa in developed countries and to develop new agents．There are many factors that can cause prostate cancer，including aging，inheritance，hormone level and energy balance．Currently，the treatment of prostate cancer includes surgery and radiation therapy．Combination drug therapies for prostate cancer provide a new direction．The combination of different drugs may be an effective therapy for inhibiting the growth of prostate cancer wim less side effect and lower toxicity This study focused on the mechanisms by which chol esterol affects the growth and sensitivity of prostate cancer cells to docetaxel，and the mechanisms for growth inhibition and apoptosi s induction by docetaxel alone or in combination with chol eSterol-lowering drug atorvastatin．Prostate cancer PC一3 and LNCaP cells were used to investigate the effects and mechanisms of cholesterol and the drug combination．Cell growth and apoptosis were determined by the trypan blue exclusion assay and morphological assessment of cells stained with propidium iodide．NF-KB activity was determined by luciferase reporter gene assay and the Western blot assay was used to determine the levels of Bcl-2，phospho-Akt,VEGF,and phospho-Erk 1／2．Results showed that lower concentrations of docetaxel in combination with amrvastatin produced a stronger inhibitory effect than docetaxel at higher concentrations in vitro and vivo．In the present studY,we found that pre—treatment with cholesterol decreased the inhib