中德双边会议-远江.pptVIP

Biological importance of oligomerization of stilbenes + Why trimer were synthesized, though their antioxidant activities were lower? SC50= 26.28 μg/ml SC50= 118.10μg/ml SC50= 172.1 μg/ml SC50= 16.40 μg/ml Ref. 11: A new class of phytoalexins from grapevinesExperientia 1977, 15, 151-152. Resveratrol Non-antifungal Antifungal Antifungal Hypothesis: Is peroxidase catalysing oligomerization an antifungal activity promoting reaction? Antifungal activities of stilbenes + Non-antifungal Antifungal Not tested. * Inhibition rate of growth of Botrytis cinerea(灰葡萄孢菌) at 400μg/ml. Non-antifungal Antifungal activities of stilbenes + + Non-antifungal Antifungal Not tested. Non-antifungal Antifungal activities of stilbenes + Non-antifungal Non-antifungal Antifungal Need more evidence to prove the hypothesis that oligomerization promotes antifungal activity. Inhibition rate of growth of Botrytis cinerea(灰葡萄孢菌) at 400μg/ml. Mol concentration of resveratrol was 3 fold higher than compound 8. Summary 10 stilbene oligomers were isolated from the EA extract of Parthenocissus laetevirens. Five of them are new compounds. Their structure were elucidated by NMR and MS data. Their biogenetic relationship was proved by photochemical transformation and enzyme catalysing oligomerization. Their antioxidant activities were assayed. The results led to the hypothesis that UV induced cyclization is an antioxidant activity promoting reaction and consequently stilbenes were implied to play a role in the antioxidative defense system of the plant. In addition, the results of antifungal activities reveal that enzyme catalysing oligomerization may be linked to the antifungal defense system of the plant J. Org.Chem. 2008 Resveratrol Hexamer from Vitis chunganeniss J. Org.Chem. 2009 Proposed chunganenol biogenesis (1) from 3 and 5 Driving Force Compds DPPH radical IC50 (μM)a 1 37.3±0.8 2 188.3±3.7 3 251.6±5.9 4 62.2±2.5 5 138.1±3.5b 6 42.4±1.1b 7 115.8±4.0b 8 73.2±2.3b vitamin E 33.6±1.3 a IC50 val