45例木村病的临床分析.doc

木村病临床分析 武汉大学人民医院 刘立梅 高清平* 王则胜 王琼玉，武汉 430060 摘要 目的：探讨木村病的临床表现、诊断及治疗特点。 方法：回顾性分析我院2001年至2014年经病理检查确诊的45例木村病的临床资料。 结果：45例均以局部包块为主要表现，23例累及头面部，11例累及颈部，此外还有腹股沟3例，胸壁3例，腹壁3例，髂前上棘1例，锁骨1例；16例血常规示嗜酸性粒细胞比例增高，其中嗜酸性粒细胞绝对值增高的有13例；2例血清IgE水平显著升高。多使用手术切除或糖皮质激素治疗。 结论：木村病是少见病，诊断主要依据临床表现、血常规、病理检查等，手术切除或激素治疗后联合小剂量的放疗可有效预防复发。 关键词 木村病 淋巴肉芽肿 嗜酸性粒细胞增多 IgE增高 Clinical Analysis of Kimura’s disease LIU Limei GAO Qingping* WANG Zesheng,et al. Renmin Hospital of Wuhan University,Wuhan 430060,Chain Abstract Objective:To explore the clinical characteristics,diagnosis and the therapeutic effect of kimura’s disease. Method:clinical date of 45 patients who diagnosed with kimura’s disease by histopathologic biopsy from 2001 to 2014 in our hospital were analyzed retrospectively. Result：All the patients presented with location masses,23 cases involved in head region,11 cases in neck region,and the other regions such as inguinal region (3 case),chest wall (3 cases),abdominal wall (3 cases), HYPERLINK F:/Dict/554/resultui/app:ds: anterior superior spine \t F:/Dict/554/resultui/_self anterior superior spine(1 case),collarbone(1 case). 16 cases showed high rates of eosinophil,and 13 cases of them had raised eosinophil counts. The serum IgE level were measured in 3 cases,and we found 2 cases increased remarkable.Many of the patients chose surgical excision or HYPERLINK F:/Dict/554/resultui/app:ds:hormonotherapy \t F:/Dict/554/resultui/ hormonotherapy. Conclusion:kimura’s disease is an infrequent disease.The diagnosis based on clinical manifestation,blood routine test,pathological examination and so on.Low dose of radiotherapy is necessary for preventing relapse. key words Kimura’s disease;Lymphogranuloma;Eosinophilia;Elevated serum IgE 木村病（kimura’s disease，KD）是一种局部慢性良性淋巴组织增生性疾病；最早于1937年由我国外科医生金显宅以“嗜酸性粒细胞增生性淋巴肉芽肿”为名报道[1]，1948年日本kimura详细报道,此后国际上多以kimura’s disease命名此病，称作木村病。本病还有“嗜酸性淋巴肉芽肿”，“嗜酸性粒细胞性淋巴结病”、“嗜酸性粒细胞性滤泡增生症候群”、“软组织嗜酸性肉芽肿”等名 通信作者：高清平，E-mail：gao.qingping@163.com 称。木村