密闭性中药海绵敷料的制备研究.PDF

中草药 Chinese Traditional and Herbal Drugs 第 45 卷 第 4 期 2014 年 2 月 ·485 · 密闭性中药海绵敷料的制备研究 1 2 3 4 1* 潘永毅 ，刘 强 ，蔡保塔 ，谢文鸿 ，蔡文智 1. 南方医科大学护理学院，广东 广州 510515 2. 南方医科大学中医药学院，广东 广州 510515 3. 南方医科大学珠江医院，广东 广州 510280 4. 南方医科大学南方医院，广东 广州 510515 摘 要：目的 优选密闭性中药海绵敷料的最佳成型工艺。方法 采用正交设计法，以海绵的吸水率、保湿性、透气率为评 价指标，对海绵的基质配比、加药浓度、交联剂用量进行优选研究。结果 密闭性中药海绵敷料的最佳成型工艺：海绵基质 配比为聚乙烯醇-壳聚糖- 明胶 1 ∶3 ∶1；中药复方提取液浓缩为 15 ∶3 ；交联剂戊二醛用量为0.7 mL 。结论 海绵敷料的成 型工艺稳定、切实可行，为产品后期产业化发展提供依据。 关键词：密闭性中药海绵敷料；正交试验；医用高分子；吸水率；保湿性；透气率 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2014)04 - 0485 - 05 DOI: 10.7501/j.issn.0253-2670.2014.04.007 Preparation of airtight Chinese medicine sponge dressings 1 2 3 4 1 PAN Yong-yi , LIU Qiang , CAI Bao-ta , XIE Wen-hong , CAI Wen-zhi 1. School of Nursing, Southern Medical University, Guangzhou 510515, China 2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China 3. Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China 4. Nanfang Hospital of Southern Medical University, Guangzhou 510515, China Abstract: Objective To optimize the forming procedure of airtight Chinese medicine sponge dressings. Methods The forming procedure was investigated by orthogonal design, and the matrix ratio, drug concentration, and glutaraldehyde dosage were studied with water absorption, moisture, and permeability as evaluation indexes. Results The optimal forming procedure was as follows: the matrix ratio of polyvinyl alcohol-chitosan-gelatin was 1 ∶3 ∶1, the extracting solution of Chinese medicine compound was concentrated to 15 ∶3, and the dosage of glutaraldehyde was 0.7 mL. Conclusion The established forming procedure is stable and practicable, and laying a solid foundation for futur