脆弱拟杆菌的研究进展.PDF

微生物学通报 Jul. 20, 2015, 42(7): 1366−1371 Microbiology China © 2015 by Institute of Microbiology, CAS tongbao@ DOI: 10.13344/j.microbiol.china.140778 专论与综述 脆弱拟杆菌的研究进展 冯淑贞 张和平* (内蒙古农业大学 乳品生物技术与工程教育部重点实验室 内蒙古 呼和浩特 010018) 摘 要：脆弱拟杆菌是定殖于哺乳动物肠道中的共生菌，同时也是临床感染病例中常见的条件致 病菌。本文从致病及益生特性两大方面综述脆弱拟杆菌的研究现状，着重讨论了脆弱拟杆菌作为 潜在益生菌在预防和治疗糖尿病及免疫性疾病中所起的重要作用，从而为筛选及应用益生脆弱拟 杆菌菌株提供一定的参考。 关键词：脆弱拟杆菌，耐药性，益生菌 The research progress of Bacteroides fragilis * FENG Shu-Zhen ZHANG He-Ping (Key Laboratory of Dairy Biotechnology and Engineering Ministry of Education, Inner Mongolia Agricultural University , Hohhot, Inner Mongolia 010018, China) Abstract: Bacteroides fragilis is one of the symbiotic anaerobes within the mammalian gastrointestinal tract and is also an opportunistic pathogen which often isolated from clinical specimens. To provide reference for probiotic candidates screening, this article reviewed the pathogenicity and probiotic properties of Bacteroides fragilis, especially focused on the potential effects of Bacteroides fragilis as probiotics on prevention and treatment of diabetes and immune disease. Keywords: Bacteroides fragilis, Drug resistence, Probiotics 科学的进步使人们深入认识肠道菌群成为可 到外界环境、饮食习惯以及疾病等的影响而失衡 能，对于这一天然的健康“保护伞” ，科学家们逐渐 时，会对宿主的健康产生威胁。从婴儿到成人，肠 对其实现了从无到有、从浅到深的探索研究。目前 道菌群的构成经历了从兼性好氧菌到厌氧菌的转 已认识到人体肠道菌群主要由硬壁菌门、拟杆菌 变，最终形成以厌氧菌为优势菌的成人肠道菌群结 门、变形菌门以及放线菌门构成[1] 。肠道菌群的组 构[6]。 成和结构与宿主健康状况息息相关，在正常状况