血浆和肽素、N末端脑钠肽前体和肾上腺髓质素前体N端20肽与慢性心力.doc

血浆和肽素、N末端脑钠肽前体和肾上腺髓质素前体N端20肽与慢性心力衰竭的关系研究*该项目受重庆市卫生局资助(2011-2-547); *该项目受重庆市卫生局资助(2011-2-547); 何艺1?通讯作者，何艺，女，重庆市黔江中心医院，副主任医师，Email：heyi0721@163.com、冉华1、王正中1、张艳芳1、王丽1、郑全1、梁泊平1 ?通讯作者，何艺，女，重庆市黔江中心医院，副主任医师，Email：heyi0721@163.com (1：重庆市黔江中心医院心内科，重庆409000) (2：重庆医科大学附属第二医院，重庆400016) [摘要] 目的：探讨血浆和肽素(copeptin)、肾上腺髓质素前体N端20肽(PAMP)、N末端脑钠肽前体(NT-proBNP)水平和慢性心力衰竭(CHF)及其严重程度的相关关系。 方法：分别入选CHF患者72例和32例非CHF对照，检测纳入对象血浆copeptin、PAMP和NT-proBNP水平，心脏彩超评价心脏的结构和功能。 结果：CHF患者血浆copeptin、NT-proBNP水平与对照组相比明显升高(p0.001)，并随NYHA分级的增加而升高。Copeptin分别与左室舒张末期内径(LVEDD)值、血肌酐、NYHA分级、NT-proBNP呈显著正相关(p0.01)，与左室射血分数(LVEF)呈负相关(p0.01)。CHF患者血浆PAMP水平对照组相比无显著差异。 结论：血浆copeptin、NT-proBNP水平在CHF中显著升高，并与CHF的严重程度密切相关。 关键词：慢性心力衰竭；和肽素；肾上腺髓质素前体N端20肽；N末端脑钠肽前体 [中图分类号]：R541.7 [文献标志码]:A The relationship between plasma copeptin, ProAdrenoMedullin N-terminal 20 Peptide, N-terminal pro-brain natriuretic peptidelevels and chronic heart failure He Yi1, Ran Hua1, Wang Zhengzhong1, Zhang Yanfang1, Wang Li1, ZhengQuan1, Liang bopping1, Pu Yi1, Yin Yuehui2 (1: Department of Cardiology,Qianjiang Central Hospital, Chongqing, 409000) (2: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016) ABSTRACT Objective: To investigate the relationship between plasma copeptin, ProAdrenoMedullin N-terminal 20 Peptide (PAMP), N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and the severity of chronic heart failure (CHF). Methods: Seventy-two patients with CHF and 32 non-CHF controls were enrolled. Plasma copeptin, PAMP concentrations were measured byenzyme-linked immuno sorbent assay, and the concentration of NT-proBNP was detected by Triaged detection instrument. Results: Plasma copeptin and NT-proBNP levels in patients with CHF were significantly higher than that in non-CHF controls(p0.001), and which were elevated with the increase of the New York Heart Association (NYHA) Class. The concentration of copeptinhad a parallel with left ventricular end-diastolic diamet