丁卡因凝胶处方研究药物化学专业论文.docxVIP

丁卡因凝胶处方研究Formulation 丁卡因凝胶处方研究 Formulation Research of Tetracaine Gel Abstract Tetracaine iS a Na+blockers，potent local anesthetic，mainly used local anesthesia and spinal anesthesia．At present，the clinical use of the drug dosage forms are injections and gels． Pain is a chronic and widespread medical problems，hospital and community are widespread， pain relief is an important therapeutic goal．Survey shows that pain limits the patient’S functional status，affects their quality of life，and weaks their ability to work．The main advantage lies in its topical anesthesia application process is painless，as local anesthesia infiltration doesn’t destroy tissue．Painless treatment，especially minor surgery as provided venipuncture pain treatment for pediatric patients is critical．In a busy emergency room，the main disadvantage of using topical anesthesia iS anesthesia onset time． Tetracaine clinical use is limited by its high penetration delay time(35 to 40min)．Because it iS usually set before venipuncture or intravenous tube used，SO the delay time can be redu【ced to improve the effecfiveness of the drug to patients．And in the formulation，tetracaine iS unstable．storage inconvenient．It is also an important reason for limiting its use．nlis paper is mainly based on these two points，to improve formulations of tetracaine． The purpose of this article is by optimizing the penetration enhancers and drug matrix，to develop a tetracaine prescription with quick onset of action and convenient storage．Choose to use the skin of nude mice when measuring vitro percutaneous kinetic parameters of tetracaine． Ks／v of tetracaine is 5．1 9，and this suggests that liposoluble of tetracaine is too large，the stratum comeum and stratum comeum to allocation of active transdermal skin significantly affect the behavior of tetracaine．In this study，by using the addition of chemical penetration enhancers，and we hope to improve tetracaine percutaneous penetration．In order to study the influence of a variety of chemic