蛋白质芯片技术检测agvhd患者22种血清生物标志物的临床意义内科学血液病学专业论文.docxVIP

第三军医大学硕士学位论文TLR4 第三军医大学硕士学位论文 TLR4 Toll—like receptor 4 Toll样受体4 TNFRl Tumor necrosis factor receptor 1 肿瘤坏死因子受体1 vWF von Willebrend factor 血管假血友病因子 TF Tissue factor 组织因子 LPS lipopolysaccharide 脂多糖 STAT signal transducer and activator of transcription信号转导因子和转录激活因子 MSC Mesenchymal stem cells 间充质干细胞 IL．1RAcP interleukin-1 receptor accessory protein 白介素1受体辅助蛋白 2 万方数据 第三军医大学硕士学位论文Clinical 第三军医大学硕士学位论文 Clinical significance of protein chip technology in detection of 22 serum biomarkers in patients with aGVHD． Abstract objective： Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is effective method to treat variety of hematologic malignancies．Acute graft versus host disease(aGVHD)is common complication after allogeneic hematopoietic stem cell transplantation，which seriously affects the quality of life and survival rate of patients，which is the main cause of non recurrent death in allo-HSCT patients．At present，the diagnosis of aGVHD mainly depends on the clinical manifestations and pathological examination of the damaged target organs．But its clinical symptoms various and lack of specificity,and pathological examination often because of various not be carried out in clinical diagnosis and treatment，SO that the timeliness of its diagnosis was affected．Therefore，to explore some of the clinical practical，noninvasive，fast monitoring methods of aGVHD，SO that patients in the early of the immune activation state can be diagnosed and treated early as possible，SO that more effective control of aGVHD，which is an urgent need to solve clinical problem． Protein chip technology is new technology which combines microelectronics，micro mechanics，chemistry and life science．And it has the characteristics of high throughput， high specificity,high sensitivity，miniaturization，automation and SO on．In this study,22 serum biomarkers of aGVHD and non aGVHD patients after allogeneic hematopoietic stem cell transplantation were detected by sandwich membrane protein chip technology．And to