聚合物纳米粒子载药体系的研究进展.pdfVIP

22 1 河 北 工 业 科 技 Vol. 22, No . 1 2005 1 H ebei Journal of Industrial Science and Technology Jan. 2005 : 100 -1534( 2005) 01-003- 06 , , , ( 河北科技大学化学与制药工程学院, 河北石家庄 05001 ) : 聚合物纳米粒子是一种新型的药物载 , 具有小粒子特征, 可以穿越生物膜屏障, 到达传 统药物无法到达的人 特定部位, 建立起新的给药途径; 聚合物载 的多变性又可赋予药物许多新 的特点, 因而引起广泛关注按预聚物分散和单 聚合2 种方法, 介绍了载药聚合物纳米粒子的制 备方法以及粒子的表面修饰; 描述了粒子的粒度形貌相对分子质量Zeta 电位及热性能的表征 方法; 介绍了其应用现状; 对聚合物纳米粒子载药 系的发展方向提出了建议 : 聚合物纳米粒子; 药物载 ; 制备方法; 性能; 应用 : R94; T Q314 : A Study on polymer nanoparticles in drug delivery system SHANG Q ing, ZHENG He-tang, YAN Li, SHI Yong-li ( College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology , Shijiazhuang H ebei 05001 , China) Abstract : Polymer nanoparticles as drug carrier syst ems is a new kind of drug delivery system. It is easy to get to site-specific through biofilm barrier for the nanoparticles. Polymer nanopart icles have new characterist ics for multiformity of polymeric ma- terial, so polymer nanoparticles em ployed as drug carriers have att racted attention. In this review , the tw o preparative methods for dispersion of the preformed polymers and polymerization of monomers are expounded, t he measuring method of particles di- ameter, modality, moleculer w eight, Zeta potent ial and thermic performance are investigated, and the applications are discussed. At last are the suggestions on development t rend for polymer nanoparticles as drug carrier. Key words: polymer nanoparticles; drug carriers; preparation methods; performance; applications , , , [ 1~ 3] , ; , : pH , Zeta ; , , , , , , , , , ; 10~ 1 000 nm, , : 2004-0