应用血流向量成像技术研究原发性高血压左室能量损耗.PDFVIP

• 260 • Journal of Biomedical Engineering, Apr. 2017, Vol. 34, No.2   ·论 著· 应用血流向量成像技术研究原发性高血压 左室能量损耗 1 2 3 1 张文 ，张艳梅，刘志月，黄鹤 四川大学华西医院 心内科（成都  610041 ） 【摘要】   本研究旨在运用血流向量成像技术（VFM ）研究原发性高血压患者左心室能量损耗差异，尽早检 出流场力学异常的高血压患者，早期预防靶器官损害，并初步探索反映原发性高血压患者心脏舒缩功能变化的新 方法。纳入健康志愿者 22 例、左室心肌质量指数（LVMI ）正常的高血压患者 14 例及 LVMI 升高的高血压患者 21 例作为研究对象，分别行常规超声心动图、VFM 检查及双频脉冲多普勒检查。结果显示高血压病例组的左室能 量损耗明显高于正常组（P 0 . 0 5 ），且舒张期能量损耗= 0 . 4 3 9 × S B P （收缩压）– 8 . 3 4 9 ，收缩期能量损 耗=0.385×SBP+0.644×LVMI–10.854 ；左室舒缩期能量损耗与 E/e 相关，但与左室射血分数（EF ）不相关。研究表 明左室能量损耗有助于发现高血压患者流场力学变化；左室能量损耗变化是否能成为评估左室舒张功能的新指 标，尚需深入研究；SBP 是舒张期能量损耗的独立预测因素，LVMI 及 SBP 是收缩期能量损耗的独立预测因素。 【关键词】  血流向量成像技术；左室能量损耗；高血压；心功能 Dissipative energy loss within the left ventricle detected using vector flow mapping technology in hypertension 1 2 3 1 ZHANG Wen , ZHANG Yanmei , LIU Zhiyue , HUANG He Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China Corresponding author: HUANG He, Email: xhehuang@ 【Abstract 】 We have tried to explore the energy loss (EL) within the left ventricle in hypertension by using vector flow mapping (VFM) to detect left ventricular hemodynamic changes in hypertensive patients as early as possible and reflect changes of left ventricular function in hypertension by using EL. Twenty-one hypertensive patients with increased left ventricle mass index (LVMI), 14 hypertensive patients with normal LVMI and 22 control subjects were enrolled in this study. Systolic and diastolic EL derived from VFM within the left ventricle and E/e by dual Doppler were recorded and analyzed. Compared with those of the controls, diastolic and systolic EL were significantly increased in hypertensive group (P0.05). In diastole, EL=0.439×SBP (systolic blood pressure)–8.349; in systole, EL=0.3