高脂肪日粮引起肥胖和代谢综合征的分到子机制ppt课件.pptxVIP

Molecular Mechanisms of High Fat Diet-Induced Obesity and Metabolic Syndromes高脂肪日粮引起肥胖和代谢综合症的分子机制;Modern high fat diet (HFD) and overfeeding;HFD lead to obesity;How HFD induces obesity?;Systemic energy surplus leads to obesity;Storage of nutrient-derived energy surplus;Adipocytes store HFD-derived “fat”;HFD leads to adipocyte hypertrophy;HFD also leads to adipocyte hyperplasia;HFD further changes the color of fat;Three types of adipocytes：origin， function;White, beige and brown fat have distinct role in energy balance;HFD leads to whitening of fat ;抑制Notch信号通路促进白色脂肪组织的棕色化并减轻肥胖;Notch Signaling