cx3cr1基因多态性与劲动脉狭窄的关系神经病学专业论文.docxVIP

The The Relationship between CX3CRl PolymorphiSillS and Carotid Artery StenosiS Abstract Ob jective To study the association of V2491 and T280M polymorphisms of Fractalkin receptor CX3CRl with carotid artery stenosiS． Methods 318 patients with carotid artery stenosiS(CAS)diagnosised using color duplex ultrasound criteria were studied and compared with 292 subjects without carotid artery stenosiS．V249I and T280M polymorphic genotypes of CX3CRl were determined by polymerase chain reaction——restriction fragment length polymorphism(PCR—RFLP)and sequencing analysis． Results The genotypes of MM and TM were associated wi th reduced ri sk of carotid artery stenosiS，the frequency of genotype MM+TM in the two groups being 22．6％and 31．2％respectively(OR=O．646，95％CI：0．451—0．928：P=O．017)， the frequency of M allele was significantly lower in CAS than those without CAS(13．8％and 19．2％respectively，ORO．677，95％C1 0．499—0．918，P=O．010)．No di fferences were observed in the II，VI，or VV genotype，the frequency of genotype II+VI in the two groups being 39％and 43。8％respectively(ORl．012， 95％C1 0．731—1．403，P=O．940)，The genotypes of II and VI in patients with stable plaques were more frequent than in vulnerable plaques(95％C1 0．387—0．962，户O．033)．Multiple Logistic regression analysis revealed that the genotypes of MM and TM were an i ndependent ri sk factor for carot i d artery stenosiS(ORl．847，95％CI 1．091—3．127，P=O．022)． Conclusion The genotypes of MM and TM are independent risk factors for carot i d artery stenosi S，and the genotypes of II and VI are associated with the stabi 1 ity of carotid artery plaques． Postgraduate student：Zhengmin(Neurology) Directed by：Zhangchen(Professor) Key words CX3CRl；carotid aretry stenosis；atherosclerosis；polymorphisms 学位论文独创性声明学位论文独创性声明 学位论文独创性声明 学位论文独创性声明 本人声明，所呈交的学位论文系本人在导师指导下独立完成的研究成果。 文中依法引用他人的成果，均已做出明确标注或得到许可。论文内容未包含 法律意义上已属于他人的任何形式的研究成果，也不包含本人己用于其他学 位申请的论文或成果。 本人如违反上述声明，愿意承担由此引发的一切责任和后果。 论文作者签名： 智童芟 日期：沏艿年占月用 学位论文知识产权权属声明 本人在导师指导下所完成的学位论文及相关的职务作品，知识产权