灯盏细辛对青光眼神经保护作用的临床研究.PDFVIP

维普资讯 眼科研究2003年6月第2l卷第 3期 307 · 临 床 研 究 · 灯盏细辛对青光眼神经保护作用的临床研究 叶长华 蒋幼芹 A clinicalstudyoftheneur0pr0tecti0neffectofErigeronBreviscapus Hand-M azzonglaucomatouspatienteyes YeChanghua，Jiang~buqin．DepartmentofOphthalmology，SecondXiangyaHospital， CentralSouthUniversity，Changsha410011 Abstract Objective Toevaluatetheneuroprotectioneffectoferigeronbreviscapus(vant)hand-nlazz(EBHM)on patientswith intraocularpressurecontrolled—glaucoma． M ethods A prospective，randomized，double-masked，placebocontrol clinicaltrialwasconducted．45patients(eyes)withmoderateandlateglaucomawereenrolledandrandomlyassignedtoEBHM groupandage-matchedplacebocontrolgroup．Follow—up visitswere scheduledeverymonth Thefollowingtestswereperofrmed ． atthebeginningandateveryvisit：IOP，correctedvisualacuity，C／Dratio，visualfield(Twinfield，OCULUS，Germany)，heart rateandbloodpressure． Results ThelOPwas14．17±2．50mmHgand 14．52±1．94mmHgforEBHM andcontrolgroups． respectively(P：0．598)for6months．After6nmnths，meansensitivity(MS)increased1．42dBinEBHMgroup，anddropped 0．95dBincontrolgroup (P=0．000)．TherateofvisualfieldimprovementinEBHM andcontrolgroupswas56．52％ and 4．55％ ．respectively (P ：0．001)．NosystemicsideeffectsrelatedtoEBHM werefound． Conclusions EBHM could improvevisualfield in patientswith lOP controlled-glaucoma． When lOP wasbelow 15mmHg，EBHM haslessrisk forthe glaucomatousopticneurupathyant]greatereffecton reducingthevisualfiehldefects．EBHM therapy showsfavorable effecton patientswithmoderateandlateglaucoma． Keywords glaucoma neuroprotection intraocularpressure erigeronbreviscapus(vant)ha