·专家述评·帕金森病的发病机制、诊断标准及治疗策略.PDFVIP

Med J Chin PLA, Vol. 43, No. 8, August 1, 2018 　631 ·专家述评· 帕金森病的发病机制、诊断标准及治疗策略 梁建庆 梁建庆，医学博士，副教授。现任中华中医药学会中医诊断学分会青年委员，世界中医药联 合会急症专业青年委员。主要致力于帕金森病的研究，已发表学术论文30余篇，参编专著3部。目 前主持/参与国家自然科学基金项目各1项，主持中国博士后科学基金项目1项，甘肃省中医药管理 局项目1项。2013年获甘肃省皇甫谧中医药科技二等奖。 [摘要]　帕金森病(PD)是一种好发于中老年人的常见的神经系统退行性疾病。我国65岁以上人群PD 患病率为 1700/10万，且随年龄增长逐渐升高，给家庭和社会造成了沉重负担。PD 的发生是多种因素如遗传、环境、年龄老化 α 等综合作用的结果， -突触核蛋白、氧化应激、DNA 甲基化、神经营养因子、线粒体自噬、神经递质、神经炎症、 miRNA 、钙的细胞毒作用、免疫学异常、细胞凋亡等多种机制，均可引起黑质多巴胺能神经元变性而导致PD发病。本 文重点介绍导致黑质多巴胺能神经元变性的致病因素，以及PD 的识别、防治策略与技术。 [关键词]　帕金森病；多巴胺能神经元；诊断；治疗策略 [中图分类号]　R742.5　　　　[文献标志码]　A　　　　[文章编号]　0577-7402(2018)08-0631-05 [DOI]　10.11855/j.issn.0577-7402.2018.08.01 Pathogenesis, diagnosis and treatment strategies of Parkinsons disease LIANG Jian-qing Department of Diagnosis of Traditional Chinese Medicine, School of Basic Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China This work was supported by the National Natural Science Foundation of China , the Open Foundation of Key Laboratory of Dunhuang Medicine and Transformation co-constructed by the Ministry of Education and Gansu Province (DHYX1516-08), and the Scientific Research Fund for Young and Middle-Aged Scholars of Gansu University of Traditional Chinese Medicine (ZQ2015-17) [Abstract]　Parkinsons disease (PD) is a common degenerative disease of the middle-aged and old people. The prevalence of PD in the people over 65-years is 1700/100 thousand, and is increasing with age, which has caused a heavy burden to the family and society. PD is a comprehensive effect of various factors such as genetic factors, environmental factors, aging, alpha synuclein, ox