氟苯尼考与黏菌素联用对猪大肠杆菌与链球菌的体外-河南农业科学.PDF

DO I :10.15933/j .cnki .1004 -3268.2008.09.030 2008 年第9 期 ＊ 康　宇, 律海峡,胡功政 ,刘建华, 潘玉善 ( , 450002 ) :采用棋盘法, 测定了氟苯尼考与黏菌素联用对猪大肠杆菌、链球菌分离株的体外抗菌 性。 结果表明:猪大肠杆菌、链球菌分离株均对氟苯尼考呈现出耐药性, 其最小抑菌浓度(M IC )为0 .64 ～5.12 mg/L,大部分大肠杆菌分离株对黏菌素耐药, 仅对其中一株有明显效果。棋盘法测得氟苯 尼考与黏菌素联合对猪大肠杆菌、猪链球菌分离株的部分抑菌浓度(F IC )指数为 0.0 3126 ～ 0.14063,均为协同作用。当浓度大于或等于0.16 m g/L 时即呈现出协同作用。 :氟苯尼考;黏菌素;联合用药;抗菌 性;猪大肠杆菌;猪链球菌 :S859.79 　　:A 　　:1004 3268 (200 8)09 0116 04 I n v it ro A ntibacterial A ctivity o the Com bination o Flor enicol and Colistin Sul ate on E scherich ia co li and S trep tococcus Isolated rom Pigs ＊ KA NG Y u, L ¨U H ai-xia, H U Go ng-zheng , LIU Jian-hua,P A N Yu-shan (College o A nima l Science and V eterinary M edicine, Henan A g ricultural Univ ersity,Zhengzhou 4 50002, China) Abstract:T he in v it ro antibact eri al act ivities o lor enicol and colistin sul a te ag ainst the Esche - ri ch ia co li and S trep tococcus i solat es derived ro m pig s w ere i nvestig ated by checkerboard method i n t his paper .T he result s show ed that bo th o t he E .col i and S tr ep tococcus isola tes w ere to lerant to lor enico l and the minimum i nhibit ory concent ratio ns (M IC)w ere 0.64 -5.12 mg/L .M ost o the E .col i iso lates w ere resistant to colistin sul ate except one case .When used co mbi ned, the ractio nal inhibit ory co ncent ratio ns (FIC)o lor enicol and co list in sul ate varied rom 0.03 126 to 0.140 63, and represent ed the synergistic e ect s w hen t he co ncent ratio n exceed or equal t o 0.16 mg/