细胞穿膜肽研究概况.pdfVIP

Advances in Marine Sciences 海洋科学前沿, 2018, 5(2), 29-37 Published Online June 2018 in Hans. /journal/ams /10.12677/ams.2018.52004 Review on the Research of Cell-Penetrating Peptides 1 1 1 1,2* Yueru Chen , Mengxi Wu , Qian Hu , Huarong Guo 1 Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao Shandong 2 Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao Shandong th th rd Received: Apr. 26 , 2018; accepted: May 16 , 2018; published: May 23 , 2018 Abstract Although biomacromolecules play an important role in the treatment of many diseases, its practical application is limited due to the natural barrier of the cell membrane. Cell-penetrating peptides are a kind of small molecular peptides with remarkable capacity for membrane translocation and can carry various macromolecules into cells including peptides, proteins, nucleic acids, and so on, opening a new way for exogenous substances to enter into cells. As a novel delivery tool, CPPs have promising application prospect. In this paper, we reviewed the classification and transmembrane mechanism of CPPs, and its use in the cancer therapy and marine biology as carrier. Keywords Cell-Penetrating Peptides, Structure, Classification, Transmembrane Mechanism, Cancer Therapy, Marine Biology 细胞穿膜肽的研究概况 1 1 1 1,2* 陈月如 ，毋梦茜，胡 倩 ，郭华荣 1 中国海洋大学海洋生命学院，海洋生物遗传学与育种教育部重点实验室，山东 青岛 2 中国海洋大学海洋生物多样性与进化研究所，山东 青岛 收稿日期：2018年4月26 日；录用日期：2018年5月16 日；发布日期：2018年5月23 日 摘 要 生物大分子在许多疾病的治疗中发挥着重要的作用，但由于细胞膜的天然屏障作用，使得这些生物大分