基于Cu3BiS3的多功能纳米材料在生物成像和光热治疗上的应用-无机化学专业论文.docxVIP

Shanghai Shanghai Normal University Master of Philosophy Abstract 万方数据 万方数据 Abstract Over the past decade, cancers have become one of the major causes of mortality in the world. Current clinical therapy methods, including radiation therapy, chemotherapy, hormone therapy and immunotherapy, are often associated with severe side effects. For this reason, there is an urgent need to develop new approaches for cancer treatment. Photothermal therapy (PTT), which emerges in recent years, is considered as a new technique for cancer treatment. PTT specifically ablates the tumor tissues without harming normal tissues. In this paper, Cu3BiS3 ternary chalcogenide nanomaterials, which combine diagnosis and therapy functions into one system, were synthesized by using cheap raw materials and simple synthesis method, then the toxicity in vitro and in vivo, CT imaging and PTT effects of the obtained nanomaterials were studied. Then Cu3BiS3 nanomaterials were functionalized for multi-mode imaging and PTT functions. The full text is divided into four chapters. In the first chapter, we first introduce some nanomaterials containing metal elements with high atomic number as CT contrast agents for CT imaging. And then the inorganic nanomaterials used as photothermal agents for PTT are summarized, including different structures of gold materials, carbon based nanomaterials, palladium nanosheets, copper sulfide nanomaterials and other new nanomaterials. Finally, the research ideas of this paper were proposed. In the second chapter, we first discuss the influence of different conditions on the size and morphology of the resulting Cu3BiS3 nanoparticles, mainly including solvent system, reaction temperature and time, and finally, the optimal conditions for preparing Cu3BiS3 were obtained. Then the surface of hydrophobic Cu3BiS3 nanoparticles was modified with polyvinyl pyrrolidone (PVP) to produce hydrophilic Cu3BiS3/PVP. The methyl thiazolyl tetrazolium (MTT) assay was performed to evaluate th