冷冻干燥法制备羟基磷灰石多孔支架-硅酸盐学报.PDF

· 432 · 硅 酸 盐 学 报 2009 年 第37 卷第3 期 硅 酸 盐 学 报 Vol. 37 ，No. 3 2 0 0 9 年 3 月 JOURNAL OF THE CHINESE CERAMIC SOCIETY March ，2009 冷冻干燥法制备羟基磷灰石多孔支架 1 1 1,2 1 1 赵 康 ，魏俊琪 ，罗德福 ，汤玉斐 ，徐 雷 (1. 西安理工大学材料科学与工程学院，西安 710048 ；2. 西华大学材料科学与工程学院，成都 610039) 摘 要：采用冷冻干燥法制备出多孔羟基磷灰石(hydroxyapatite，HA)支架，观察了支架的微观形貌，研究了HA 浆料固含量和孔隙率、冷冻速率和孔 径尺寸的关系。结果表明：通过调整工艺参数可以使制备出的多孔支架的孔隙率和平均孔径尺寸分别在45%～85%、100～800 µm 之间变化，孔的连 通性较好。支架孔隙率随着浆料固含量的降低而升高，孔隙率最高可达到85%。孔径尺寸随着冷冻速率的升高而减小，减小的速度不断降低。当冷冻 速率在 1.3～3 ℃/min 之间变化时，孔径尺寸约为800～300 µm；当冷冻速率分别为9 ℃/min 和11 ℃/min 时，得到支架的孔径尺寸却相差不大，在90～ 110 µm 之间。 关键词：羟基磷灰石；冷冻干燥；多孔；支架 中图分类号：TB321 文献标志码：A 文章编号：0454–5648(2009)03–0432–04 FABRICATION OF HYDROXYAPATITE POROUS SCAFFOLDS BY FREEZE DRYING ZHAO Kang1 1 1,2 1 1 ，WEI Junqi ，LUO Defu ，TANG Yufei ，XU Lei (1. School of Materials and Engineering, Xi′an University of Technology, Xi′an 710048; 2. School of Materials and Engineering, Xihua University, Chengdu 610039, China) Abstract: Porous hydroxyapatite (HA) scaffolds were fabricated by freeze drying, and their microstructures were observed. The rela- tionship between slurry concentration and porosity was investigated, and the influence of cooling rate on pore size was considered. The results show that by changing the process parameters, the porosity can be transformed in the range from 45% to 85%, and the pore size can be transformed between 100 µm and 800 µm. The scaffolds are characterized by well-defined pore connectivity. With the reduction of slurry concentrat