同种异体皮质骨板重建压力侧骨皮质缺损的试验研究-海南医学.PDF

Vol.23 No.1 January 2012 doi:10.3969/j.issn.1003-6350.2012.01.009 ·实验研究· 同种异体皮质骨板重建压力侧骨皮质缺损的实验研究 * 张 伟，闵 珊，毛 勇 ( 中山大学附属第一医院，广东广州510080) 【摘要】 目的 在建立山羊动物模型基础上，探讨同种异体皮质骨板重建压力侧骨皮质缺损的特点，为临 床治疗提供依据。方法 将16 只成年山羊随机分成两组，制作压力侧骨皮质缺损的动物模型，8 只行植骨、骨 板、钢板固定作为实验组，另8 只行植骨、钢板固定作为对照组。3 周、9 周后取标本，进行生物力学测试，测试标 本的抗扭转、抗压缩刚度数据。随后标本制作病理切片，观察组织病理学变化。结果 对照组3 只动物内固定术 后失效，骨折端移位。实验组动物均愈合良好。病理结果显示实验、对照组3 周纤维愈合，9 周时基本达到骨性 愈合。生物力学测试结果显示：术后0 周、术后3 周标本的抗扭转、抗压缩刚度两两比较差异具有统计学意义，9 周后差异无统计学意义。结论 同种异体皮质骨板能够为骨皮质缺损区提供可靠的初始固定稳定性，预防钢板 内固定术失效，给骨缺损愈合提供稳定的力学环境。 【关键词】 骨皮质缺损；压力侧；同种异体皮质骨板 【中图分类号】R-332 【文献标识码】A 【文章编号】 1003—6350（2012 ）01—022—04 Allogeneic cortical bone plate in the reconstruction of bone cortical defect of pressure side. ZHANG Wei, MIN Shan, MAO Yong . The First Affiliated Hospital of SUN Yat-sen University, Guangzhou 510080, Guangdong, CHINA 【Abstract 】 Objective To investigate the characteristics of using allogeneic cortical bone plate in the re- construction of bone cortical defect of pressure side through goat model, and to provide basis for clinical treat- ment. Methods Sixteen adult goats were randomly divided into group A (n=8, treated by bone graft, bone board, and plate fixation) and group B (n=8, treated by bone graft and plate fixation), Specimens were collected three weeks and nine weeks later for biomechanical test. Data of anti-twist and anti-compression were tested. Then pathological section was made to observe histopathological changes. Results In the control group, 3 cases