细丝蛋白A在细胞黏附和迁移中的作用-中国细胞生物学学报.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(8): 1142– 1152 DOI: 10.11844/cj cb.2014.08.0050 综 述 细丝蛋白A在细胞黏附和迁移中的作用 * 朱 丹 项世龙 薛智敏 王美惠 周斌全 傅国胜 (浙江大学医学院附属邵逸夫医院心内科, 杭州310016) 摘要 细胞迁移在发育、伤口愈合、炎症反应和肿瘤转移等多种病理生理过程中发挥重要 作用。细丝蛋白A(filamin A, FlnA)是一种在各组织细胞中广泛表达的微丝结合蛋白, 其表达异常 导致细胞迁移功能障碍。该文回顾了相关的文献, 首先介绍生理情况下细丝蛋白A 的功能, 接着介 绍细丝蛋白A基因突变和表达异常导致的多种遗传性疾病及其与肿瘤转移的关系, 突出细丝蛋白A 对迁移的影响在这些疾病发病中的作用, 最后深入探讨了细丝蛋白A影响细胞迁移和黏附的可能 机制。 关键词 微丝; 细胞黏附; 细胞迁移; 细胞膜结构 Role of Filamin A in Cell Adhesion and Migraion Zhu Dan, Xiang Shilong, Xue Zhimin, Wang Meihui, Zhou Binquan*, Fu Guosheng (Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China) Abstract Cell migration is essential for development, tissue remodeling and wound healing, and is ab- normal in many pathological states. Filamin A is an actin-binding protein and is widely expressed in various cell types. Mutations in filamin A gene are the cause of a wide range of genetic diseases, while abnormality in filamin A expression is resposible for cancer metastasis. Filamin A regulates cytoskeleton rearragement and palys a pivotal role in cell shape determination. Depletion of filamin A leads to obvious cell migration defects. In this review, we discuss the implication of filamin A in genetic diseases and cancer metastasis, emphasizing the impact of cell mi- gration defects on these diseases. Further more, we discuss the role of filamin A on cell migration and its underlying mechanism. Key words actin cytoskeleton; cell adhesion; cell migration; cell membrane structure 细丝蛋白A(filamin A, FlnA)是非肌性肌动蛋 一个氨基端肌动蛋白结合结构域(actin binding do-