基于蛋白网络聚类的基因功能研究-计算机系统结构专业论文.docxVIP

Resear(3h Resear(3h oN genic fun(3tion by cIustering on protein network In post-genome era,tlle objective of functional genomics study is to decode the functions of genes and control them．Since the proteins interacting with each other tend to have similar cellular functions,we咖．following the route of“interactions-network- functions竹infer the potential functions of unknown proteins by comparing them with proteins of known functions from the latest protein，protein interaction network and other high-throughput experimental data．Starting with the researching on the visualization of network,tlle clustering on multiple sources data with temporal and spatial information,and modularized clustering．we plan on developing new algorithms to solve the problems on functional proteomics and compare tIl咖with other methods in multifarious ways．Finally。 we will combine tlle methods with the soRware of visualizations of network and analyze the proteins functions ofbudding yeast systemically． We provide a simple but inform撕on-rich approach for visualization,which integrates topological and biological information．In 0111method,the topological information like quasi-cliques or spoke-like modules of t11e network is extracted into a clustering tree， where biological inform撕on spanning from protein functional annotation to expression profile correlations can be annotated onto the representation of it．We have developed a software named PINC based on our approach．Compared witll previous clustering methods．our clustering method A蜊performs welI both in retaining a meaningful image of the protein interaction network as well as in enriching the image with biological information．therefore is more suitable in visualization of也e network． We presented a simple hierarchical clustering algorithm that goes a long way to integrate high-throughput data into investigations of the systematic and dynamic organization of biolo西cal networks．Our method effectively reveals the modular structure of tlle yeast pr