胃癌组织EGFRHER-2与TopoⅡα的表达及临床意义梁秀菊1高明1.DOC

胃癌组织EGFR、HER-2与TopoⅡα的表达及临床意义 梁秀菊梁秀菊，女，郑州大学第一附属医院肿瘤科在读研究生 梁秀菊，女，郑州大学第一附属医院肿瘤科在读研究生，恶性肿瘤内科治疗与应用基础，电话邮箱liangxiuju2008@163.com 1高明，男，郑州大学第一附属医院肿瘤科，主治医师，恶性肿瘤内科治疗与应用基础。 周云 通讯作者 男 河南省人民医院肿瘤科 主任医师 教授，硕士研究生导师，研究方向：恶性肿瘤内科治疗与应用基础。E-mail：zhouyun1336@ 郑州大学第一附属医院肿瘤科 郑州 450052 【摘要】目的：研究EGFR、HER-2、TopoⅡα在胃癌组织中的表达与临床病理特征之间的关系，探讨其做为分子靶点指导胃癌分子靶向治疗的临床意义。方法：应用免疫组化方法检测108例胃癌及22例正常胃组织中EGFR、HER-2、TopoⅡα的表达情况，分析三者的表达与临床病理特征之间的关系，并对其相关性进行分析。结果：108例胃癌组织中EGFR、HER-2、TopoⅡα阳性表达率分别为41.67%、31.5%、53.7%，22例正常胃组织阳性表达率分别为和0% 、0%、4.5%。EGFR、HER-2、TopoⅡα蛋白的高表达与胃癌的部位、细胞分化程度、浸润深度、淋巴结转移及TNM分期均呈正相关；而与患者的性别、年龄及肿瘤的大小无明显关系。EGFR与HER-2；EGFR与TopoIIα；HER-2与TopoIIα的表达均呈正相关。结论：EGFR、HER-2、TopoⅡα在胃癌组织表达增高与胃癌的发生发展密切相关，EGFR、HER-2、TopoⅡα在胃癌组织高表达为胃癌分子靶向治疗提供了理论依据。 【关键词】 胃癌；EGFR；HER-2；TopoⅡα；靶向治疗 中图分类号：735.2 文献标识码：A Expression and clinical significance of EGFR、HER-2、TopoⅡα in gastric cancer [Abstract]Objective:To investigate the expression of EGFR、HER-2、TopoⅡα in gastric cancers and their relation-ship with clinical pathologic character. Explore theirs clinical significance as the molecular targets to guide the molecular targeted therapy of gastric. Methods:Expressions of EGFR,HER-2 and TopoⅡα proteins in 108 gastric cancer tissue samples and 22 normal tissue samples were detected with immunohistochemical staining.,to analyze the relationship between the expression of EGFR、HER-2、TopoⅡα and the correlation between them.Results:The expression rates of EGFR,HER-2 and TopoⅡα protein in gastric cancer tissue samples were 41.67%, 31.5% and 53.7%.respectively in normal tissue samples were 0%, 0% and 4.5%. EGFR,HER-2 and TopoⅡα expression were not correlated with the patients sex, age, tumor size, but with the location or the degree of differentiation,depth of invasion, clinical stage, lymph node and distant metastasis of the tumors. EGFR,HER-2 and TopoⅡαexpressions were positive correlation.Conclusion: EGFR,HER-2 and TopoⅡα expression in gastric cancer is closely related to the incidence increased the development o