基于机器学习方法的蛋白质相互作用位点及二级结构预测-计算机应用技术专业论文.docxVIP

ABSTRACT安徽大学 ABSTRACT 安徽大学 2009 届硕士学位论文 PAGE PAGE IV ABSTRACT Protein usually represents its function through interactions between biological molecules. Identifying protein-protein interaction sites plays an important role in protein’s function. Research on the functions of proteins should know the structure of the proteins, as structure determines function. Functions and structures of life, they are unified. Predicting protein-protein interaction sites and the structure of proteins may be determined by means of experiments, but they are very time-consuming and almost impossible. Thus the scientists have being sought after the theoretical or computational methods for predicting protein-protein interaction sites and the structure of proteins. Therefore, this paper based on SVM and BP neural network, studied on predicting protein-protein interaction sites and the structure of proteins. The main work can be introduced as follows: Predicting of protein-protein interaction sites with SVM From the primary sequence, adjacent residue sequences profile and sequences profile combines with entropy are as two kinds of input vectors for three sliding information windows(Win3, Win7, Win11) of residues, and interaction sites are classified by Support Vector Machine (SVM). The results of using SVM predicting every surface residue is whether interaction site or not, have proved the validity and feasibility of this method. The results show that: With 3 kinds of information windows, the results of using adjacent residue sequences profile combines with entropy as input vector are higher than those using adjacent residue sequences profile as input vector. It shows that the character between sequences profile and entropy are complementary for each other, and the complement is good for the predicting of protein-protein interaction sites. Meanwhile, the time-consuming of those two input vector are almost the same. With the two input vector, the classification accuracies of Win7 and Win