基于埃洛石的载药凝胶小球的制备及性能研究-中国科学院.PDF

22 7 Vol. 22, No. 7 2010 7 Chem ical Research and Application Ju ly, 2010 : 100416 6( 2010) 0708 806 1, 2 1 1* 汪 琴 , 张俊平, 王爱勤 ( 1. , 730000; 2. , 100039) : g / / ( CTSgPAA /HT /SA) HT; pH ( DS): HT , HT 30% , 12h 3284% 9107% 100% ; , pH ; pH = 21 DS , pH = 68 ; DS : ; ; pH ; ; : O6361 : A Preparation and properties of drug loaded hydrogel beads based on halloy site 1, 2 1 1* WANG Q in , ZHANG Junp ing , WANG A iQ in ( 1. Lanzhou Institute of Chem ical Physics, ChineseA cadem y of Sciences, Lanzhou 730000, Ch ina; 2. G raduate University of the Ch inese Academ y of Sciences, Beijing 100049, Ch ina) A b stract: A novel hydrogel bead, ch itosangpoly( acrylic acid) / halloys ite / sodium alginate, was prepared by the ion ic gelation m ethodE ffects of halloysite content on sw elling property, encapsulation efficiency and drug release for drug loaded in the com pos ite hydrogel beads were investigatedA pH sensitive and the release k inetics of d iclofenac sod ium from the hydrogel beads w ere also studiedThe results indicated that the halloys ite con tent obvious influenced the swelling ratio, encapsu lation efficiency and diclofenac sodium cum ulative release of the d iclofenac sodium loaded hydrogel beads. The b iggest sw elling ratio w as 3284, the encapsu lation efficiency w as 9107 % and the cum ulative release after 12h was 100% w hen HT content was 30% In add ition, the hydrogel beads had good pH sensitiveD iclofenac sod ium ( DS) in the hydrogel beadsw as hardly released in pH 21 buffer solut