基底细胞癌与毛母细胞瘤鉴别相关分子标记物的-中华临床医师杂志.PDF

中华临床医师杂志( 电子版)2014 年2 月第8 卷第4 期 Chin J Clinicians(Electronic Edition),February 15,2014,Vol.8,No.4 ·775 · ·综述· 基底细胞癌与毛母细胞瘤鉴别相关分子标记物的 研究进展 孙成帅 丁跃明 潘云 【摘要】 基底细胞癌与毛母细胞瘤在治疗和预后方面有很大的不同。过去由于对两者的分类和 诊断比较混乱，给临床治疗带来诸多不便，也给患者增加了不必要的痛苦。这就要求临床医师能及 时、准确、有效地鉴别诊断基底细胞癌和毛母细胞瘤。临床上，尤其在病理上，明确鉴别两者很困 难。近些年，随着分子生物学技术的发展，从免疫组织化学和遗传学等方面对两者的研究增多，为 我们提供一些新的鉴别依据。本文综述几种近年来研究较多的用于两者鉴别诊断的分子生物学标记 物AR 、CD10、Ln5γ2 、Nestin 、PHLDAl 和CK20 的进展。 【关键词】 肿瘤，基底细胞； 毛母细胞瘤； 鉴别诊断； 生物学标志物 Advances in research on molecular biological markers for the differential diagnosis of basal cell * * carcinoma and trichoblastoma Sun Chengshuai , Ding Yueming, Pan Yun. Clinical Medical College of Dali University, Dali 671000,China Corresponding author: Pan Yun, Email: panyun09@163.com 【Abstract 】 Basal cell carcinoma has much difference with trichoblastoma in therapy and prognosis. In the past years, due to the lack of definite classification and distinctions of basal cell carcinoma and trichoblastoma, misdiagnosis and mismanagement were often encountered and the patients underwent inappropriate treatment. So we must differentiate basal cell carcinoma from trichoblastoma early and accurately. It is difficult to distinguish them distinctly only by clinical presentation and pathologic features. In recent years, with the development of molecular biology, research in immunohistochemisty and genetics have increased, and provide us some new identification. This review article mainly describes the recent development of molecular biological markers AR, CD10, Ln5γ2, Nestin, PHLDAl and CK20 for the differential diagnosis of basal cell carcinoma and trichoblastoma. 【Key words 】 Neoplasms, basal ce