载甲钴胺香蕉纤维微晶PLGA介孔材料的制备及性能.docxVIP

·PAGE 10· 精细化工 FINE CHEMICALS 第35卷 第*期 作者等:文章题目 ·PAGE 9· 第35卷第*期 精细化工 Vol.35, No.* 功能材料2018年*月 FINE CHEMICALS *. 2018 功能材料 载甲钴胺香蕉纤维素微晶/PLGA介孔材料的制备及其性能 庞锦英，黄春艳，谭登峰，莫羡忠，蓝春波*，刘钰馨 （广西师范学院 化学与材料科学学院，广西 南宁 530001） 摘要：从香蕉树皮中提取香蕉纤维素微晶，将甲钴胺、香蕉纤维素微晶和乳酸-羟基乙酸共聚物(PLGA)制备成载甲钴胺香蕉纤维素微晶/PLGA介孔材料。运用SEM、比表面积及孔径分析仪（BET）、热重-质谱联用仪(TG-MS)和FTIR对产物进行了表征；采用紫外分光光度计对载甲钴胺介孔材料进行了载药率、包封率、体外释放度测定。红外谱图分析表明，所制备的香蕉纤维素微晶的主要成分为纤维素；BET法测定结果表明，载甲钴胺香蕉纤维素微晶/PLGA介孔材料的平均孔直径[（4V(孔体积)/A(表面积)）]为17.89nm；TG-MS结果表明，载甲钴胺香蕉纤维素微晶/PLGA介孔材料分解温度约为300℃；体外释放实验表明，该材料对甲钴胺有较好的控释作用，药物释放遵循零级释放动力学方程。关键词：香蕉纤维素微晶；甲钴胺；介孔材料；载体；缓释；功能材料中图分类号：TQ 文献标识码：A 文章编号： Preparation and Properties of Banana Microcrystalline Cellulose/PLGA Mesoporous Materials Loading Mecobalamin PANG Jin-ying, HUANG Chun-yan, TAN Deng-feng, MO Xian-zhong, LAN Chun-bo*, LIU Yu-xin （College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, Guangxi, China） Abstract: The banana microcrystalline cellulose was prepared by the banana fiber, and the esoporous materials were prepared by the mecobalamin, banana microcrystalline cellulose and PLGA. The esoporous materials were characterized bythe SEM, specific surface area and pore size analysis (BET), Thermogravimetric -mass spectrometry (TG-MS) and FT-IR. The drug load content, encapsulation efficiency, and in vitro release rate of mesoporous materials loading mecobalamin were studied by the UV spectrophotometry. FT-IR spectrum analysis showed that the main component of microcrystalline cellulose was cellulose. The BET results showed that the average pore diameter [4V(pore volume)/A(surface area)] of banana microcrystalline cellulose/ PLGA mesoporous materials loading mecobalamin was 17.89nm. TG-MS results showed that the decomposition temperature of the materials were about 300 ℃. The results indicated that the materials had great control release ability, the drug release following zero-order release kinetics. Key words: banana microcrystalline cellulose; mecobal