金匮肾气丸对大鼠实验性慢性肾衰竭性勃起功能障碍的影响及机理研究-中西医结合临床(男科)专业论文.docxVIP

戚帮中藏嚣太擘疆士攀位谂文中文摘要 戚帮中藏嚣太擘疆士攀位谂文 中文摘要 茸懿：建立慢稳鹜液渴性勃越秘麓漳褥大鬣模懑，并探讨众蔽瞥气丸辩畿 性肾栽啜大风勃起功能的影响及作爝枧理。 蠢法：疲捐SD雅能大蘸分醐避行5／6鼹陵秘除零，建立橙犍骛袭游凌 物模墅，不黼时期注射#醚}鸥雄露瀚察太鬣瓣罄勃起情况，筛逸搜往臀焱蝣性 勃起功熊潞礴模型大鼠；造模2髑藉，用金匮肾气翘混悬液灌鬻，连续30天； 寒次绘蕊勰小时爱，雕}晦毽}簿邃实验评俊大辫麓起凌煞妖凝，楚歹乏詹溺鬣焱 清睾酮及服掰、尿豢氨水平。光镜缀合图形分析系统观察黎煅阴茎维绒的摄 微结梅。 缕菜：畿毪鹜栽鳎羧赣起耱熊辩褥大器l巍游聚黻浓发显著隆骶，魏越次数 懿显下降，彤语F、藤豢氮明显开嵩。漤丸、阴蕊缀织漫微结构发熊明篮瘸璞瞧 改交：鞲熬海绵体平滑胍禽量下降、聚丸生精小黪数避减少、管径缩小以及阚殿 缨躲数爨减少；金滠鹜气丸可霞漫豫跨衰竭瞧勃怒渤麓瘁褥大藏备矮援拣搭裁 不两程度的恢复，蕊蒸放肇丸嚣徽络构的变他得黻戳复，攀丸系数增加，擞潦 肇酮恢笈正常，勃越功熊明显改善。 缝谂：5／6胬照韬豫零结合瓣枣}鹎蹲戆逡嶷埝哥复裁畿馁褥裘蝎性翁麓襄 能障礴大鼠模型，并艇阿朴嚼啡筛选可作为评价慢性臀衰竭大躐勃起功能的瓒 想方法。幔性肾衰竭严黧影响戳鎏戳起功能、减少雄激素的合成分泌、损密冁 茎海终舔勃越维缓获聚戴秘爨微络魄，雄激豢降德、勃起擎缘的羧少萄麓麓莛 主要发辩机理。金瞬蟹气丸可有效浚蛰慢性肾慧蜗大鼠的熟越功能，冀作掰梳 理可能与敬馨酾茎、嚣丸的显微结构歉肾功熊、增加睾丸系数、增加虫演辫粼 含量蠢笑。 笑镰谲：金箧‘鼯气丸慢往肾褒瓣勃起功麓障碍掰朴嚼掰}睾醚佟 爝机理蜜验研究 成都中嚣药大学硬±学位论定Abstract 成都中嚣药大学硬±学位论定 Abstract objective：To creat the sprague—dauley(SD)rat model of Erectile Dysfunction in Chronic Renal Failure，tO observe erectile function in a rat model of chronic renal failure，and explore the mechanisms which chronic renal failure carl lead tO erectile dysfunction，and the therapeutic effect ofJin Gui Shen Qi Wan’Oil erectile function． Methods：chronic renal failure was induced by adult male Sprague-Dawtey rats， which were subjected tO all excisional 5／6 nephrectomy．Injected with apomorphine， penile erections were observed and noted on the 2th week．8血week and 12m week from the 146 day of 5／6 nephrectomy and experimental models of ED with CRF were selected，Two weeks later，Jin Gui Shen Qi Wansuspension was perfused,mto their stomachs．After 30 days，to evaluate the erectile function by the injection with apomorphine，then the concentration oftestosterone、8erllm creatirtine and blood uria nitrogen were examined；The microstructure of testes and penile were observed under optical microscope with B12000 computer configuration image analysis system． Results：The concentration of testosterone decreased significantly and the sigfiificant pathological changes in rat model of Erectile Dysfunction in Chronic Renal Failure：The decrease ON numb