肽脯氨顺反异构和分子伴侣-中国科学院计算技术.ppt

肽脯氨顺反异构酶和分子伴侣 宓怀风 吸附分离功能高分子材料国家重点实验室 南开大学 化学院高分子化学研究所 生物化学实验室 The prolyl-peptidyl-cis/trans isomerase catalyzes the isomerization of the N-terminal peptidyl bound of proline PPIase Drug binds to PPIase and suppress  its PPIase activity  is used as immunosuppresant  by organ transplatation  Cyclophilin Cyclosporin A 亲环素 环胞菌素A FKBP FK506 (FK506 binding protein) Schematic comparison of hCyP33 with hCyP18, hCyP40 and RanBP Schematic comparison of FKBP23 with FKBP12 hCyP33 binds specifically to mRNA FKBP23 in ER binds to BiP Publications (1) Mi HF. Kops O. Zimmermann E. Jaschke A. and Tropschug M. A nuclear RNA-binding cyclophilinb in human T cells. FEBS Letters, 398(2-3):201-205, Dec. 1996 IF 3.5 (2) Jaeschke A. Mi HF. and Tropschug M. Cyclophilin 18 binds to antioxidant protein Aop1 and stimulates its activity. Biological Chemistry. Special supplement, 378:7, Sept. 1997 IF 2.4 (3) Jaeschke A. Mi HF. and Tropschug M. Human T cell Cyclophilin 18 binds to Thiol specific antioxidant protein Aop1 and stimulates its activity. Journal of Molecular Biology, 277:763-769, Feb. 1998 IF 6.2 (4) Oliver K. Fischer G. Eckerskorn S. Mi HF. and Tropschug M. Ssp1, a novel parvulin from Neurospora crassa with a polyglutamine module: a site specific proryl isomerase active in protein folding. Journal of Biological Chemistry, 273:31971-31976, Dec. 1998 IF 7.8 (5) Fair K. Anderson M. Bulanova E. Mi H. Tropschug M. and Diaz MO. Protein interactions of the mll phd fingers modulate mll target gene regulation in human cells. Mol. Cell Biol., 21(10):3589-3597, May 2001 IF 9.6 (6) 张万起, 元云峰, 王亦农, 袁 直, 宓怀风*, 何炳林. 人T细胞中核酸结合亲环素(hCyP33)与poly(A)+RNA(mRNA)特异