外用青黛治疗桥本甲状腺炎疗效及其对甲状腺自身免疫性抗体的影响.PDF

·24· Chinese Journal of Information on TCM Nov.2014 Vol.21 No.11 外用青黛治疗桥本甲状腺炎疗效 及其对甲状腺自身免疫性抗体的影响 张毅,张敏,黄宁静 上海市中医医院内分泌科,上海 200071 摘要 ：目的 观察外用青黛对桥本甲状腺炎 (HT)血清中甲状腺球蛋白抗体 (TGAb)、甲状腺过氧化物酶抗体 (TPOAb)的影响。方法 将 65 例 HT 患者随机分为治疗组 33 例和对照组 32 例。2 组甲状腺功能亢进、甲状腺 功能减退者分别予甲巯咪唑片 10 mg/d、左旋甲状腺素片 25～50 μg/d 控制甲状腺功能,稳定 2 周后,治疗组在 此基础上于颈前甲状腺投射区域局部外敷青黛治疗,疗程 6 个月。结果 中医临床证候2 组均有改善,组间比 较差异有统计学意义 (P ＜0.05,P ＜0.01)。治疗组中医证候疗效为 81.82%(27/33),对照组为 65.63%(21/32), 2 组比较差异有统计学意义(P ＜0.01)。治疗组临床疗效总有效率为 84.85%(28/33),对照组为 71.88%(23/32), 2 组比较差异有统计学意义(P ＜0.05)。治疗组治疗后血清 TGAb、TPOAb 水平较治疗前下降 (P ＜0.05),2 组 比较差异有统计学意义(P ＜0.01)。结论 外用青黛治疗 HT 可提高疗效,并能有效降低甲状腺自身免疫性抗 体指标。 关键词 ：青黛；桥本甲状腺炎；甲状腺球蛋白抗体；甲状腺过氧化物酶抗体；中医药疗法 DOI：10.3969/j.issn.1005-5304.2014.11.008 中图分类号：R259.814 文献标识码：A 文章编号：1005-5304(2014)11-0024-04 Efficacy of Indigo Naturalis Topical Treatment of Hashimoto’s Thyroiditis and Its Effects on Serum TGAb and TPOAb ZHANG Yi, ZHANG Min, HUANG Ning-jing (Endocrinology Department, Shanghai Traditional Chinese Medicine Hospital, Shanghai 200071, China) Abstract ：Objective To observe the efficacy of topical indigo naturalis on the serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in Hashimotos thyroiditis (HT). Methods Sixty-five cases of HT were randomly divided into the treatment group (33 cases) and the control group (32 cases). Hyperthyroidism patients and hypothyroidism patients in the two groups were treated with methimazole 10 mg/d and levothyrocine 25-50 μg/d to control their thyroid function. Based on the basic treatment, patients in the treatment group were treated with topical indigo naturalis local external application, which lasted for 6 months. Results TCM clinical symptoms