脑血管病患者血浆神经肽Y和神经降压素浓度的测定及意义研究.PDFVIP

维普资讯 JApoplexyandNervousDiseases，April2005，Vol22，No．2 16O 文章编号：1003—2754(2005)02一Ol60—03 脑血管病患者血浆神经肽Y和神经降压素浓度 的测定及意义研究 南光贤 ， 崔明姬 ， 王利平 ， 顾春梅 摘 要 ： 目的 研究脑血管病患者在缺血和出血状态下，血浆神经肽Y(NPY)和神经降压素 (NT)含量与脑 血管病的关系。方法 用放射免疫方法测定脑血管病患者缺血、出血状态下NPY和NT含量。结果 出血性脑血 管病患者血浆神经肽Y较对照组有显著提高。缺血性脑血管病患者血浆神经肽Y较对照组无显著差异。脑出血患 者的血浆NT含量较正常对照组显著升高 ，脑梗死患者的血浆NT含量较正常对照组显著降低 。结论 出血性脑血 管病患者血浆神经肽Y和NT均升高且随病情的好转而降低。缺血性脑血管病患者血浆NT含量降低 ，且随病情的 好转而升高，与血浆神经肽Y无关。 关键词： 神经肽Y； 神经肽Y受体； 神经降压素； 脑血管病 中图分类号：743 文献标识码：A StudyontheplasmaNPY andNT contentsofpatientswithcerbrovasculardiseases NAN Guang—xian。CUIMing— ji，WANGLi—ping，ela1．(DepartmentofNeurology，China—JapanUnionHospitaltlIilinUniversity，Changchun 130031．China) Abstract： Objective TostudytherelationshipbetweenNPYandNTcontentsofpatientswithcerebrovas— culardiseasesunderischemicaswellashemorrhagicstates．M ethods NPY andNT contentsinplasmaweredeter— minedbyradioimmunologicaltechnologyinpatientswithcerebrovasculardiseases．Results NPY contentsinplas— maofpatientswithhemorrhagiccerebrovasculardiseaseswassignificantlyhigherthanthatincontrolgroup．NPY contentsinplasmaofpatientswithischemiccerebrovasculardiseaseswasnosignificantlydifferentwiththatincon— trolgroup．NT contentsinplasmaofpatientswithhemorrhagiccerebrovasculardiscaseswasevidentlyhigherthan thatincontrolgroup．NT contentsinplasmaofpatientswith ischemiccerebrovasculardiseaseswassignificantly lowerthatincontrolgroup．Conclusion NPYandNT contentsinplasmaofpatientswithhemorrhagiccerebrovas— culardiseasestendtOlaw with improvementofpatientsstatus．NT contentsinplasmaofpatientswith ischemic cerebrovasculardiseasesissignificantlylowerthanthatin controlgroup．AswellastheNT contentstendtOim— provewith