基于微阵列数据构建基因调控网络-遗传.PDF

HEREDITAS (Beijing) 2007 12 , 29(12): 1434―1442 ISSN 0253-9772 综述 DOI: 10.1360/yc-007-1434 刘万霖, 李栋, 朱云平, 贺福初 , , , 100850 : 随着微阵列数据的快速增长, 微阵列基因表达数据日益成为生物信息学研究的重要数据源。利用微阵列 基因表达数据构建基因调控网络也成为一个研究热点。通过构建基因调控网络, 可以解读复杂的调控关系, 发 现细胞内的调控模式, 并进而在系统尺度上理解生物学进程。近年来, 人们引入了多种算法来利用基因芯片数 据构建基因调控网络。文章回顾了这些算法的发展历史, 尤其是其在理论和方法上的改进, 给出了一些相关的 软件平台, 并预测了该领域可能的发展趋势。 : 微阵列时间序列; 基因调控网络; 贝叶斯网络; 布尔网络 Constructing gene regulatory network from microarray data LIU Wan-Lin, LI Dong, ZHU Yun-Ping, HE Fu-Chu State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China Abstract: With the rapid deposition of the microarray data in recent years, microarray data has increasingly become an important data source for bioinformatics research. Based on microarray date, constructing gene regulatory networks has also become a hotspot. By constructing the gene regulatory network, we can identify the complicated regulatory relationships, uncover the regulatory patterns in the cell, and gain the systematic view for biological process. Recently, many algorithms have also been introduced in this field to determine gene regulatory networks based on such high-throughput microarray data. In this paper, we review the development of these algorithms, with a particular emphasis on their improvement of the- ory and method. At last, we present the available software and platform and discuss the development trends in this field. Keywords: time-series microarray; gene regulatory network; Bayesian network; Boolean network , ,