H4SiW12O40 SiO2催化合成3,4-二氢嘧啶-2(1H)- 酮衍生物.pdfVIP

Journal of Organic Chemistry Research 有机化学研究, 2015, 3, 1-8 Published Online March 2015 in Hans. /journal/jocr /10.12677/jocr.2015.31001 Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using H4SiW12O40/SiO2 as Catalyst Xiuyun Chen, Yulin Xu, Shuijin Yang* Hubei Collaborative Innovation Center for Rare Metal Chemistry, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi Hubei * Email: yangshuijin@163.com th st th Received: Jan . 20 , 2015; accepted: Jan. 31 , 2015; published: Feb. 5 , 2015 Copyright © 2015 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract 5-Ethoxycarbonyl-4-(4-hydroxyphenyl)-6-methyl-3,4-dihydropy-rimidine-2(1H)-one was synthe- sized from 4-hydroxybenzaldehyde, ethyl acetoacetate and urea using H4SiW12O40/SiO2 as a novel eco-friendly catalyst prepared by a sol-gel technique. The influences of molar ratio of reactant, reaction temperature, catalyst dosage and reaction time were discussed. The optimum conditions are: molar ratio of 4-hydroxybenzaldehyde to ethyl acetoacetate to urea is 1:1.5:1.5; reaction tem- perature is 70˚C; catalyst dosage is equal to 2.0% of feed stocks and the reaction time is 60 min; the yield of the product is 93.1%. And the synthesis of other kinds of 3,4-dihydropyrimidine- 2(1H)-one was also tested, and the yield of the products could reach 57.6% - 95.1%. Experimental results reveal that H4SiW12O40/SiO2 is an excellent catalyst for synthesis of 3,4-dihydropy-rimi- dine-2(1H)-one and has good prospects. The catalyst and synthesis products