课件：急性心肌梗死药物治疗.ppt

后面内容直接删除就行 资料可以编辑修改使用 资料可以编辑修改使用 资料仅供参考，实际情况实际分析 主要经营：课件设计，文档制作，网络软件设计、图文设计制作、发布广告等 秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 * Anatomy of Plaque Disruption Atherosclerotic plaque rupture is the major cause of thrombosis of the coronary arteries that leads to acute ischemia and AMI.1 Plaques can be categorized as either vulnerable or stable based on their structural characteristics.2,3 Atherosclerotic plaques prone to rupture are commonly composed of a mass of soft lipids with abundant cholesterol crystals separated from the vessel lumen by a thin fibrous cap.4 Accumulation of foam cells and lipids promotes plaque instability.5 If the extracellular lipid core makes up more than 40% of the overall plaque volume, the plaque is particularly susceptible to rupture.4 Stresses from intraluminal pressure, coronary vasomotor tone, tachycardia (which increases cyclic stretching and compression), and rupture of the small nutrient vessels (vasa vasorum) in the walls of large blood vessels can combine to rupture a plaque, usually at the margin of the fibrous cap near an adjacent plaque-free segment of the coronary artery wall (shoulder region of the plaque).3,5 1. Meyer BJ, Chesebro JH. Aspirin and anticoagulants. In: Julian DG, Braunwald E, eds. Management of Acute Myocardial Infarction. Philadelphia, PA: WB Saunders Co.; 1994:163-192. 2. Libby P. Molecular bases of the acute coronary syndromes. Circulation. 1995;91:2844-2850. 3. Antman EM, Braunwald E. Acute myocardial infarction. In: Braunwald E, ed. Heart Disease, A Textbook of Cardiovascular Medicine. Philadelphia, PA: WB Saunders; 1997:1184-1288. 4. Fernandez-Ortiz A. Fuster V. Evolution of the atherosclerotic plaque. In: Rifkind BM, ed. Lowering Cholesterol in High-Risk Individuals and Populations. New York, NY: Marcel Dekker, Inc.; 1995:69-98. 5. Langer A, Armstrong PW. Treatment of acute ischemic syndromes in the absence of coronary occlusion: preventing progression