《临床药理学》中国医科大学PPT-geriatricspediatrics-wy 1.pptVIP

* * Physiological characteristics in the neonate Reduced gastric acid secretion Gastric empty delayed Underdeveloped epidermal barrier Increased skin hydration Lower plasma protein concentration Lower binding capacity of protein Hepatic oxidative metabolism and glucuronide conjugation are deficient Reduced glomerular filtration rate Renal tubular function are immature * * Physiological characteristics in the neonate * * Disasters 1. Gray baby syndrome---chloramphenicol Lack of G6PD--- chloramphenicol accumulation--toxicity does 100-300mg/kg/d, serum concentration 75-100 microg/ml vomiti