珍珠菜总黄酮渗透泵控释片的制备研究-天津中草药杂志社.PDF

12 中草药 Chinese Traditional and Herbal Drugs 41 8 2010 8 * 游本刚, 潘海敏, 许琼明, 唐丽华 , 杨世林 ( , 215 123) : 7O, , PE G400 , 45% 85% , , , : ; ; : R2 842 ; R2 8602 : A :( 2010) Preparation of osmotic pumpcontrolled release tablets of total flavones in Ly simachia clethr oides Y OU Bengang , PA N H a m n, X U Q o ngm ng, T A N G L hua, Y A N G Sh l n ( Schoo l o f Pharmacy, M ed cal Colleg e of Soo Chow U n ver s ty , Suzhou 215123, Ch na) Abstract: Objective T o prepare osmo t c pum pcont rolled release t ablet s of t ot al f lavones n Lysima chia clethroides Methods T w o com ponent s of t he ex t ract f rom Lclethroides, rut n and nar ngen n7O gluco s de w ere u sed to ev aluat e the release behav or of osm ot c pum p contr olled release t ablets S ngle fac t or nvest gat o n w as car r ed out o n t he m em brane compos t ons and or f ce var ables, and un f orm des gn w as u sed t o opt m ze the f ormulat o n of coat ng mambrane Results T he m em brane w e ght , P EG400 con t ent, and d but yl pht halot e ( DBP ) cont ent w ere t he m a n fact o rs nfluenc ng the drug release, and based on 45% and 85% of cellulose acetat e, respect vely, to prepare osmot c pumpcontr olled release tablet s could ach eve t he des red z eroor der release prof le Conclusion T he fo rmulat o n and t echnolo gy are s mple and easy t o be carr ed out . O sm ot c pumpcont rolled r elease t ablet s have a st able drug release bahav o r and a go od repro duc b l t y Key words: t ot al flavo nes o f Lysima